Detailed information of TA system TA198936

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4353825..4355413
• Replicon: chromosome
• Accession: NZ_CP072825
• Organism: Klebsiella pneumoniae strain IRQBAS103c

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: J2LTC9
• Locus tag: J9262_RS21130
• Protein ID: WP_004148372.1
• Coordinates: 4353825..4355147 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: J9262_RS21135
• Protein ID: WP_004176198.1
• Coordinates: 4355147..4355413 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9262_RS21115 (4348881)	4348881..4351382	+	2502	WP_040025883.1	fimbria/pilus outer membrane usher protein	-
J9262_RS21120 (4351370)	4351370..4352374	+	1005	WP_040025882.1	fimbrial protein	-
J9262_RS21125 (4352516)	4352516..4353808	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
J9262_RS21130 (4353825)	4353825..4355147	-	1323	WP_004148372.1	type II toxin-antitoxin system HipA family toxin	Toxin
J9262_RS21135 (4355147)	4355147..4355413	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
J9262_RS21140 (4355678)	4355678..4356004	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
J9262_RS21145 (4356001)	4356001..4356501	-	501	WP_020804988.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
J9262_RS21150 (4356479)	4356479..4357858	-	1380	WP_206552300.1	nucleobase:cation symporter-2 family protein	-
J9262_RS21155 (4358204)	4358204..4359358	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
J9262_RS21160 (4359339)	4359339..4360262	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49127.45 Da
• Isoelectric Point: 7.5357

>T198936 WP_004148372.1 NZ_CP072825:c4355147-4353825 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSLRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T198936 NZ_CP097066:c308465-308370 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT198936 WP_004176198.1 NZ_CP072825:c4355413-4355147 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT198936 NZ_CP097066:308271-308335 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Structures

Toxin

• AlphaFold DB: J2LTC9