Detailed information of TA system TA198934

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3933525..3935206
• Replicon: chromosome
• Accession: NZ_CP072825
• Organism: Klebsiella pneumoniae strain IRQBAS103c

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: J9262_RS19150
• Protein ID: WP_015959269.1
• Coordinates: 3933525..3934400 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: J9262_RS19155
• Protein ID: WP_130947194.1
• Coordinates: 3934448..3935206 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9262_RS19130 (3928831)	3928831..3930351	+	1521	WP_049005954.1	sugar ABC transporter ATP-binding protein	-
J9262_RS19135 (3930348)	3930348..3931346	+	999	WP_002885172.1	ribose ABC transporter permease	-
J9262_RS19140 (3931377)	3931377..3932318	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
J9262_RS19145 (3932393)	3932393..3933400	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
J9262_RS19150 (3933525)	3933525..3934400	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
J9262_RS19155 (3934448)	3934448..3935206	-	759	WP_130947194.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
J9262_RS19160 (3935292)	3935292..3936020	-	729	WP_004177810.1	response regulator transcription factor	-
J9262_RS19165 (3936293)	3936293..3938440	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
J9262_RS19170 (3938670)	3938670..3939356	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T198934 WP_015959269.1 NZ_CP072825:c3934400-3933525 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

>T198934 NZ_CP097061:454921-455262 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCAGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28532.93 Da
• Isoelectric Point: 10.0870

>AT198934 WP_130947194.1 NZ_CP072825:c3935206-3934448 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQAVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT198934 NZ_CP097061:454691-454921 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Structures

Toxin

• AlphaFold DB: A6TH06