Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1686331..1686950 Replicon chromosome
Accession NZ_CP072825
Organism Klebsiella pneumoniae strain IRQBAS103c

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag J9262_RS08235 Protein ID WP_002892050.1
Coordinates 1686331..1686549 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag J9262_RS08240 Protein ID WP_002892066.1
Coordinates 1686576..1686950 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9262_RS08200 (1682378) 1682378..1682641 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
J9262_RS08205 (1682641) 1682641..1682781 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
J9262_RS08210 (1682778) 1682778..1683476 - 699 WP_117260135.1 GNAT family protein -
J9262_RS08215 (1683577) 1683577..1685028 + 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
J9262_RS08220 (1685003) 1685003..1685473 - 471 WP_002892026.1 YlaC family protein -
J9262_RS08225 (1685494) 1685494..1685634 + 141 WP_004147370.1 hypothetical protein -
J9262_RS08230 (1685606) 1685606..1686172 - 567 WP_002892030.1 maltose O-acetyltransferase -
J9262_RS08235 (1686331) 1686331..1686549 - 219 WP_002892050.1 HHA domain-containing protein Toxin
J9262_RS08240 (1686576) 1686576..1686950 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
J9262_RS08245 (1687436) 1687436..1690582 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
J9262_RS08250 (1690605) 1690605..1691798 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T198923 WP_002892050.1 NZ_CP072825:c1686549-1686331 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T198923 NZ_CP097059:c2653709-2653566 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTTCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT198923 WP_002892066.1 NZ_CP072825:c1686950-1686576 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT198923 NZ_CP097059:2653449-2653633 [Enterococcus faecalis]
TGCTAGAATGTAGATGAAAAGAGAGAGATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTGAGACGGTGACCAATTGT
ATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGAAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References