Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 372130..372787 Replicon chromosome
Accession NZ_CP072825
Organism Klebsiella pneumoniae strain IRQBAS103c

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag J9262_RS01970 Protein ID WP_002916310.1
Coordinates 372377..372787 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag J9262_RS01965 Protein ID WP_002916312.1
Coordinates 372130..372396 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9262_RS01940 (367338) 367338..368771 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
J9262_RS01945 (368890) 368890..369618 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
J9262_RS01950 (369668) 369668..369979 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
J9262_RS01955 (370143) 370143..370802 + 660 WP_004174454.1 hemolysin III family protein -
J9262_RS01960 (370901) 370901..371884 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
J9262_RS01965 (372130) 372130..372396 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
J9262_RS01970 (372377) 372377..372787 + 411 WP_002916310.1 protein YgfX Toxin
J9262_RS01975 (372794) 372794..373315 - 522 WP_002916308.1 flavodoxin FldB -
J9262_RS01980 (373416) 373416..374312 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
J9262_RS01985 (374335) 374335..375048 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J9262_RS01990 (375054) 375054..376787 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T198922 WP_002916310.1 NZ_CP072825:372377-372787 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T198922 NZ_CP097059:2372750-2373094 [Enterococcus faecalis]
ATGAAAAGTATCAAAGAGTTGGTAGAAGAATATAATGTGGAGTTAGTTTTTACTACTTTGAACAAACGCGCATGTTTCGA
CCCTACCTACGGTATCATATTTGTAAATCAAAATTTAACACCATCAGAACAAGAAGAAGCAATATATCACGAGTTAAAGC
ATGTAAAAGACCATGTGGATATAATGACATTGTATAAAATTCCTGTTTTTCGTTCTAAGATGGAATCCGAAGCAGAACAA
TATATGTTTAGAAGCTTAATCGAAAAATATGAAGGACAATACAATTACTCAAATGTTATAGCTCATTACAACTTAAAAAT
GGGACAAGAAGTTTATTTGAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT198922 WP_002916312.1 NZ_CP072825:372130-372396 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT198922 NZ_CP097059:2372399-2372731 [Enterococcus faecalis]
ATGAATACTTATGAAATAATAAAAGAGTTGACAAAAAGGAAGAAAATGTCTATTCGACAATTAGAAATTACTCTAGGTTA
CTCAAATGGATATTTTAGCAAGTGGAAAAAAGTTTCTCCAAACTCAGAAGGCCTACAAAAAGTTGCGGACTACTTCAATG
TATCGGTAGATTATCTATTGGGAAGAACTGATAATACTAAAGCAACTGATGAAAAAAATTCTGATGATTTAGATGATGTA
CTGGATAACGTCATGAGTTTTGACGGTGAACCACTTGATGATCATGACAGAGAAGTTATTCGTGCATATTTAAAGGGTAG
ATTCGGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References