Detailed information of TA system TA198906

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2395232..2396915
• Replicon: chromosome
• Accession: NZ_CP072802
• Organism: Escherichia coli strain PK5074

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: J8617_RS11695
• Protein ID: WP_000361916.1
• Coordinates: 2395998..2396915 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: J8617_RS11690
• Protein ID: WP_024243514.1
• Coordinates: 2395232..2396005 (+)
• Length: 258 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8617_RS11660 (2391200)	2391200..2391925	-	726	WP_000066550.1	type 1 fimbria chaperone FimC	-
J8617_RS11665 (2391962)	2391962..2392501	-	540	WP_000824105.1	fimbrial protein	-
J8617_RS11670 (2392566)	2392566..2393114	-	549	WP_000695543.1	type 1 fimbrial major subunit FimA	-
J8617_RS11675 (2393595)	2393595..2394047	-	453	Protein_2315	type 1 fimbria switch DNA invertase FimE	-
J8617_RS11685 (2394816)	2394816..2395144	-	329	Protein_2317	IS3 family transposase	-
J8617_RS11690 (2395232)	2395232..2396005	+	774	WP_024243514.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
J8617_RS11695 (2395998)	2395998..2396915	+	918	WP_000361916.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
J8617_RS11700 (2397209)	2397209..2397376	+	168	WP_001356018.1	hypothetical protein	-
J8617_RS11705 (2397429)	2397429..2398091	-	663	WP_000357928.1	hypothetical protein	-
J8617_RS11710 (2398164)	2398164..2398805	-	642	Protein_2322	integrase arm-type DNA-binding domain-containing protein	-
J8617_RS11720 (2399286)	2399286..2400305	+	1020	WP_001299662.1	NADPH-dependent aldehyde reductase Ahr	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimH / fimG / fimF / fimD / fimD / fimC / fimI / fimA / fimE	2381049..2398091	17042

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34909.99 Da
• Isoelectric Point: 4.7040

>T198906 WP_000361916.1 NZ_CP072802:2395998-2396915 [Escherichia coli]
MDKTSPYYRQVALLVRALPWVANESCFALKGGTAINLFIHDFPRLSVDIDLAWIPLESREVALPNVREALTRIAAELEAQ
TGIRAVLQTHNPDEMRIIVTTDDAQIKIEVSPVARGTLYPPQERDIVGAVEEEFGFAALPVVSLPDLYGGKLCAALDRQH
PRDFYDVKMLLDTQGIDRSIFNGFIVYLLSHNRPLSEVLNPCWKDITEPFQNEFSGMTFEEVSLEELKEVPERMLSTLKT
HFTQQDFDFLMSFKRGEPDWNLAPEPHIQNLPAVQWKLRNIGQMSEEKRAQSLEKLEKVMTEWLR

Nucleotide

• Length: 918 bp

>T198906 NZ_CP097056:519529-519645 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin

Protein

• Length: 258 a.a.
• Molecular weight: 29319.73 Da
• Isoelectric Point: 9.9889

>AT198906 WP_024243514.1 NZ_CP072802:2395232-2396005 [Escherichia coli]
MASKLNWLLQNTSPGSLVLQSWLTRNNISPSLAFKYAQNGWLIKLRAGVYARAGREPDWSDALWCLQNQLEAPVHLAGLS
SLSWQGRSHYLQLKQNQCWLSVENKAILPKWFKEFPGVEWLMVSALKLPDLDEKYRTELEVKGKRITASTPELAAYELLS
AVPQEISFEHAAELFQGLVNLNPRKVEKLLTLSQSVQTKRLYLFFASFYEHAWFKRIDTSKINLGSGNRQIVVNGKLNTQ
YQITVPENFTKKGISHG

Nucleotide

• Length: 774 bp

>AT198906 NZ_CP097056:c519761-519556 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC