Detailed information of TA system TA198892

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 3716693..3717195
• Replicon: chromosome
• Accession: NZ_CP072801
• Organism: Thiothrix litoralis strain AS

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J9253_RS17975
• Protein ID: WP_028489823.1
• Coordinates: 3716693..3716947 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J9253_RS17980
• Protein ID: WP_028489824.1
• Coordinates: 3716944..3717195 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9253_RS17960 (J9253_17960)	3713489..3714673	-	1185	WP_210222236.1	hypothetical protein	-
J9253_RS17965 (J9253_17965)	3714700..3715389	-	690	WP_228291424.1	ABC transporter ATP-binding protein	-
J9253_RS17970 (J9253_17970)	3715526..3716659	+	1134	WP_210222237.1	hypothetical protein	-
J9253_RS17975 (J9253_17975)	3716693..3716947	-	255	WP_028489823.1	Txe/YoeB family addiction module toxin	Toxin
J9253_RS17980 (J9253_17980)	3716944..3717195	-	252	WP_028489824.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
J9253_RS17985 (J9253_17985)	3717355..3719130	+	1776	WP_210222238.1	N-acetylglutaminylglutamine amidotransferase	-
J9253_RS17990 (J9253_17990)	3719199..3719503	-	305	Protein_3568	transposase	-
J9253_RS17995 (J9253_17995)	3719476..3721113	-	1638	WP_228291596.1	polysaccharide deacetylase family protein	-
J9253_RS18000 (J9253_18000)	3721319..3722020	-	702	WP_210222240.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10155.74 Da
• Isoelectric Point: 9.3464

>T198892 WP_028489823.1 NZ_CP072801:c3716947-3716693 [Thiothrix litoralis]
MRIVFSSKAWEDYLYWQQADKKILKRINELIKAISREPFEGIGKPEPLRHGLSGYWSRRINDEHRLVYKVEGEDLLIAMC
RYHY

Nucleotide

• Length: 255 bp

>T198892 NZ_CP097046:2699847-2699990 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAACCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9337.64 Da
• Isoelectric Point: 4.6386

>AT198892 WP_028489824.1 NZ_CP072801:c3717195-3716944 [Thiothrix litoralis]
MNAISYTAVRAELAKTMDRVCEDHEPIIITRNREQAVVMISLEDYKAMEETAYLLRSPANASRLLESIAELGRGNGQARE
LLE

Nucleotide

• Length: 252 bp

>AT198892 NZ_CP097046:c2700184-2699922 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTACA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA