Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3343470..3344047 Replicon chromosome
Accession NZ_CP072801
Organism Thiothrix litoralis strain AS

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag J9253_RS16200 Protein ID WP_210221935.1
Coordinates 3343470..3343718 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J9253_RS16205 Protein ID WP_210221936.1
Coordinates 3343715..3344047 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9253_RS16175 (J9253_16175) 3339069..3341261 - 2193 WP_210221930.1 class I SAM-dependent DNA methyltransferase -
J9253_RS16180 (J9253_16180) 3341640..3341975 + 336 WP_210221931.1 hypothetical protein -
J9253_RS16185 (J9253_16185) 3341972..3342208 + 237 WP_210221932.1 hypothetical protein -
J9253_RS16190 (J9253_16190) 3342205..3343077 + 873 WP_210221933.1 replication protein -
J9253_RS16195 (J9253_16195) 3343074..3343289 + 216 WP_210221934.1 hypothetical protein -
J9253_RS16200 (J9253_16200) 3343470..3343718 + 249 WP_210221935.1 type II toxin-antitoxin system HicA family toxin Toxin
J9253_RS16205 (J9253_16205) 3343715..3344047 + 333 WP_210221936.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J9253_RS16210 (J9253_16210) 3344146..3344403 + 258 WP_210221937.1 hypothetical protein -
J9253_RS16215 (J9253_16215) 3344494..3344772 + 279 WP_028489005.1 hypothetical protein -
J9253_RS16220 (J9253_16220) 3344769..3346061 + 1293 WP_210221938.1 type II toxin-antitoxin system HipA family toxin -
J9253_RS16225 (J9253_16225) 3346058..3346399 + 342 WP_210221939.1 cupin domain-containing protein -
J9253_RS16230 (J9253_16230) 3346547..3347158 + 612 WP_210221940.1 transcriptional repressor LexA -
J9253_RS16235 (J9253_16235) 3347394..3348560 + 1167 WP_210221941.1 FimV/HubP family polar landmark protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-74)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9305.72 Da        Isoelectric Point: 8.9957

>T198891 WP_210221935.1 NZ_CP072801:3343470-3343718 [Thiothrix litoralis]
MSKLEKLLEKMGNHKATWTWHELCSLLVKLGYTQEEGDGSRVKFDNGNATDLINLHKPHPGNEVKAYVIRQVREKLTTGG
ML

Download         Length: 249 bp

>T198891 NZ_CP097046:2699847-2699990 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAACCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 11950.59 Da        Isoelectric Point: 4.8783

>AT198891 WP_210221936.1 NZ_CP072801:3343715-3344047 [Thiothrix litoralis]
MKMLEHKGYYGSIEASVEDDILFGKLEFIAALVNYEGETVHALKAAFEEAVEDYLTTCQAKGYTPEVPCKGSFNVRVGHD
LHLAAAVKAKELGISLNDFVRNAISTATPA

Download         Length: 333 bp

>AT198891 NZ_CP097046:c2699736-2699590 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References