Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VagC(antitoxin)
Location 2938824..2939215 Replicon chromosome
Accession NZ_CP072801
Organism Thiothrix litoralis strain AS

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag J9253_RS14185 Protein ID WP_210221573.1
Coordinates 2939048..2939215 (+) Length 56 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag J9253_RS14180 Protein ID WP_210221572.1
Coordinates 2938824..2939057 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9253_RS14165 (J9253_14165) 2934499..2936457 - 1959 WP_210221569.1 beta-propeller domain-containing protein -
J9253_RS14170 (J9253_14170) 2936537..2937370 + 834 WP_210221570.1 methyltransferase domain-containing protein -
J9253_RS14175 (J9253_14175) 2937385..2938722 + 1338 WP_210221571.1 NADP-specific glutamate dehydrogenase -
J9253_RS14180 (J9253_14180) 2938824..2939057 + 234 WP_210221572.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J9253_RS14185 (J9253_14185) 2939048..2939215 + 168 WP_210221573.1 hypothetical protein Toxin
J9253_RS14190 (J9253_14190) 2939373..2939750 - 378 WP_210221574.1 diacylglycerol kinase -
J9253_RS14195 (J9253_14195) 2939753..2940274 - 522 WP_210221575.1 phosphatase PAP2 family protein -
J9253_RS14200 (J9253_14200) 2940385..2941200 - 816 WP_210221576.1 DUF2189 domain-containing protein -
J9253_RS14205 (J9253_14205) 2941393..2941698 + 306 WP_210221577.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
J9253_RS14210 (J9253_14210) 2941700..2942851 - 1152 WP_210221241.1 RNA-guided endonuclease TnpB family protein -
J9253_RS14215 (J9253_14215) 2942963..2944090 - 1128 WP_210221578.1 RNA-guided endonuclease TnpB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

SpoVT-AbrB domain

(9-52)


Sequences

Toxin        


Download         Length: 56 a.a.        Molecular weight: 6403.43 Da        Isoelectric Point: 7.8292

>T198890 WP_210221573.1 NZ_CP072801:2939048-2939215 [Thiothrix litoralis]
MALKTYMLDTCICSFIQREQPLQVLQRLQQARDQHDQVVISAITYAEMRFGATNK

Download         Length: 168 bp

>T198890 NZ_CP097046:2699467-2699616 [Enterococcus faecalis]
ATGCGTATGCACGTATTTCCGAAATTCAGAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGG
GTTTGGTATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 9034.16 Da        Isoelectric Point: 4.1735

>AT198890 WP_210221572.1 NZ_CP072801:2938824-2939057 [Thiothrix litoralis]
MRTVSIFANGNNQAVRIPKDMEFSNLKELEIFREGDSLILRPTRPDWLSFAELDKADDDFLVERPDVMSDEGRFEWL

Download         Length: 234 bp

>AT198890 NZ_CP097046:c2699750-2699549 [Enterococcus faecalis]
GTTTTTTTAGGTAATTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTA
AGACGGTGACCTTTTTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCA
ATTTCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References