Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VagC(antitoxin)
Location 2380552..2380965 Replicon chromosome
Accession NZ_CP072801
Organism Thiothrix litoralis strain AS

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J9253_RS21160 Protein ID WP_210221134.1
Coordinates 2380552..2380725 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J9253_RS11560 Protein ID WP_210221135.1
Coordinates 2380729..2380965 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9253_RS11530 (J9253_11530) 2376204..2377103 - 900 WP_210221130.1 acetyl-CoA carboxylase, carboxyltransferase subunit beta -
J9253_RS11535 (J9253_11535) 2377128..2377931 - 804 WP_210221131.1 tryptophan synthase subunit alpha -
J9253_RS11540 (J9253_11540) 2377928..2379112 - 1185 WP_210224609.1 tryptophan synthase subunit beta -
J9253_RS11545 (J9253_11545) 2379288..2380304 + 1017 WP_210221132.1 SH3 domain-containing protein -
J9253_RS21155 (J9253_11550) 2380316..2380543 - 228 WP_210221133.1 PIN domain-containing protein -
J9253_RS21160 (J9253_11555) 2380552..2380725 - 174 WP_210221134.1 PIN domain-containing protein Toxin
J9253_RS11560 (J9253_11560) 2380729..2380965 - 237 WP_210221135.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J9253_RS11565 (J9253_11565) 2381034..2382245 - 1212 WP_210221136.1 RNA-guided endonuclease TnpB family protein -
J9253_RS11570 (J9253_11570) 2382642..2383262 + 621 WP_210221137.1 lytic transglycosylase domain-containing protein -
J9253_RS11575 (J9253_11575) 2383502..2384095 + 594 WP_210221138.1 sigma-70 family RNA polymerase sigma factor -
J9253_RS11580 (J9253_11580) 2384082..2384561 + 480 WP_051543295.1 cupin domain-containing protein -
J9253_RS11585 (J9253_11585) 2384575..2385423 + 849 WP_210221139.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-52)

Antitoxin

SpoVT-AbrB domain

(10-45)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6571.54 Da        Isoelectric Point: 9.0356

>T198889 WP_210221134.1 NZ_CP072801:c2380725-2380552 [Thiothrix litoralis]
MTNYRYLLDTNIISNLFREPQGNVYQHLQRVGENTVCTSIVVAAELRFGAKNVIPRF

Download         Length: 174 bp

>T198889 NZ_CP097046:c2694040-2693699 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
TTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGACAAGTAGTGATCTCACAA
CTGCAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8891.19 Da        Isoelectric Point: 5.0347

>AT198889 WP_210221135.1 NZ_CP072801:c2380965-2380729 [Thiothrix litoralis]
MQAERHVRLFRNGRNQAIHIPREFELAGNEAIIRREGNRLIIEALQRPSLLAFLAACVPSDVDFPDIDNLPPLDDVVF

Download         Length: 237 bp

>AT198889 NZ_CP097046:c2694270-2694040 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GCCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References