Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2274065..2274704 Replicon chromosome
Accession NZ_CP072801
Organism Thiothrix litoralis strain AS

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J9253_RS10980 Protein ID WP_028490159.1
Coordinates 2274288..2274704 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J9253_RS10975 Protein ID WP_028490158.1
Coordinates 2274065..2274301 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9253_RS10955 (J9253_10955) 2269910..2270626 - 717 WP_228291356.1 ABC transporter ATP-binding protein -
J9253_RS10960 (J9253_10960) 2270623..2271948 - 1326 WP_210221051.1 efflux RND transporter periplasmic adaptor subunit -
J9253_RS10965 (J9253_10965) 2271961..2273322 - 1362 WP_210221052.1 efflux transporter outer membrane subunit -
J9253_RS10970 (J9253_10970) 2273487..2273996 + 510 WP_028490157.1 DUF4405 domain-containing protein -
J9253_RS10975 (J9253_10975) 2274065..2274301 + 237 WP_028490158.1 hypothetical protein Antitoxin
J9253_RS10980 (J9253_10980) 2274288..2274704 + 417 WP_028490159.1 type II toxin-antitoxin system VapC family toxin Toxin
J9253_RS10985 (J9253_10985) 2274718..2275134 - 417 WP_210221053.1 type II toxin-antitoxin system VapC family toxin -
J9253_RS10990 (J9253_10990) 2275131..2275376 - 246 WP_028490161.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
J9253_RS10995 (J9253_10995) 2275622..2276308 + 687 WP_028490162.1 response regulator transcription factor -
J9253_RS11000 (J9253_11000) 2276311..2277666 + 1356 WP_210221054.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15845.95 Da        Isoelectric Point: 6.4023

>T198888 WP_028490159.1 NZ_CP072801:2274288-2274704 [Thiothrix litoralis]
MYLLDTNVISEIRKGQRANPGVQAFFQHVTHNHDKLFLSAVTIGELRRGIELIRYRNDHVQAHQLEQWLEQILSDYQDHI
IGLDADAAQLWGRLRVPHHEHELDKLIAASALLYDLTVVTRNVDDFAGTSVKLLNPFT

Download         Length: 417 bp

>T198888 NZ_CP097046:c2608771-2608628 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8800.26 Da        Isoelectric Point: 10.1783

>AT198888 WP_028490158.1 NZ_CP072801:2274065-2274301 [Thiothrix litoralis]
MSNLIVRKLEPEIIEALKQRAARNGRSAEMEHRAILREVLLVLKKRSLAEVLATMPNVGTDADFERIQGKQQVSDVFA

Download         Length: 237 bp

>AT198888 NZ_CP097046:2608509-2608654 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
ATATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References