Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1698407..1699032 Replicon chromosome
Accession NZ_CP072801
Organism Thiothrix litoralis strain AS

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J9253_RS08225 Protein ID WP_210224123.1
Coordinates 1698407..1698805 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J9253_RS08230 Protein ID WP_093069820.1
Coordinates 1698805..1699032 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9253_RS08205 (J9253_08205) 1693945..1694664 + 720 WP_210224120.1 ATP-binding protein -
J9253_RS08210 (J9253_08210) 1694668..1695645 + 978 WP_210224121.1 2OG-Fe(II) oxygenase family protein -
J9253_RS08215 (J9253_08215) 1696204..1697677 + 1474 Protein_1645 ISNCY family transposase -
J9253_RS08220 (J9253_08220) 1698023..1698334 + 312 WP_210224122.1 hypothetical protein -
J9253_RS08225 (J9253_08225) 1698407..1698805 - 399 WP_210224123.1 type II toxin-antitoxin system VapC family toxin Toxin
J9253_RS08230 (J9253_08230) 1698805..1699032 - 228 WP_093069820.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J9253_RS08235 (J9253_08235) 1699157..1700797 - 1641 WP_210224124.1 chaperonin GroEL -
J9253_RS08240 (J9253_08240) 1700815..1701105 - 291 WP_210224125.1 co-chaperone GroES -
J9253_RS08245 (J9253_08245) 1701204..1701677 - 474 WP_210224126.1 FxsA family protein -
J9253_RS08250 (J9253_08250) 1701756..1703750 - 1995 WP_210224127.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-123)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14839.33 Da        Isoelectric Point: 9.6916

>T198887 WP_210224123.1 NZ_CP072801:c1698805-1698407 [Thiothrix litoralis]
MKYLLDTNICIYLIKEKPPAVLVRFTALKPAQVFISAVTVFELYYGVENSQAHKRNLAALEKFLRPMTILDFTPEDAKQA
ARIRADLKRKGTPIGAYDLQIAATALANGLTVVTNNTDEFQRVVGLRLENWV

Download         Length: 399 bp

>T198887 NZ_CP097046:c2608396-2608253 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8764.85 Da        Isoelectric Point: 4.5557

>AT198887 WP_093069820.1 NZ_CP072801:c1699032-1698805 [Thiothrix litoralis]
MQTAKIFQNGRSQAIRLPKAFRLSGTEVKISRDGNRIILEPLEQSWDDWLLAIEQFSDDFMAEGRDQPAVQEREW

Download         Length: 228 bp

>AT198887 NZ_CP097046:2608497-2608695 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAATGAAAAGAGAGATATGCTTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGA
CGGTGACCGATTATATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAAGCAATT
TCACAATCAGTGCAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References