Detailed information of TA system TA198880

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 2269122..2269672
• Replicon: chromosome
• Accession: NZ_CP072800
• Organism: Candidatus Thiothrix anitrata isolate A52

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: J8380_RS11675
• Protein ID: WP_210225803.1
• Coordinates: 2269376..2269672 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J8380_RS11670
• Protein ID: WP_210225802.1
• Coordinates: 2269122..2269388 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8380_RS11650 (J8380_11650)	2265044..2265796	-	753	WP_228292204.1	TSUP family transporter	-
J8380_RS11655 (J8380_11655)	2265890..2266906	+	1017	WP_210217591.1	quinone-dependent dihydroorotate dehydrogenase	-
J8380_RS11660 (J8380_11660)	2266942..2267751	-	810	WP_210225800.1	hypothetical protein	-
J8380_RS11665 (J8380_11665)	2267964..2268983	+	1020	WP_210225801.1	beta-N-acetylhexosaminidase	-
J8380_RS11670 (J8380_11670)	2269122..2269388	+	267	WP_210225802.1	ribbon-helix-helix domain-containing protein	Antitoxin
J8380_RS11675 (J8380_11675)	2269376..2269672	+	297	WP_210225803.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J8380_RS11680 (J8380_11680)	2269769..2270326	+	558	WP_210225804.1	hypoxanthine-guanine phosphoribosyltransferase	-
J8380_RS11685 (J8380_11685)	2270328..2271065	+	738	WP_210225805.1	S-methyl-5'-thioinosine phosphorylase	-
J8380_RS11690 (J8380_11690)	2271070..2271519	+	450	WP_210225806.1	hypothetical protein	-
J8380_RS11695 (J8380_11695)	2271610..2271930	-	321	WP_210225807.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2158658..2311835	153177

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11089.64 Da
• Isoelectric Point: 6.7235

>T198880 WP_210225803.1 NZ_CP072800:2269376-2269672 [Candidatus Thiothrix anitrata]
MPQLIISDKARADIVRFHAFLKQQDVTAANNAVFTLLNAFGVLGGQPHIGRLVEDEPDLREFLVEFGNSGYVALYRYDSK
RDAVVVLTIRHQREVGYQ

Nucleotide

• Length: 297 bp

>T198880 NZ_CP072800:2269376-2269672 [Candidatus Thiothrix anitrata]
ATGCCACAATTAATTATTTCTGATAAAGCGCGGGCAGATATAGTCCGGTTTCATGCCTTTCTGAAACAACAAGATGTGAC
GGCTGCGAATAATGCGGTCTTTACCCTGCTGAATGCTTTTGGTGTCTTGGGGGGGCAGCCACACATCGGGCGGTTGGTGG
AGGATGAACCTGATTTGCGGGAGTTTTTGGTGGAATTTGGTAATAGTGGTTATGTTGCACTGTATCGTTATGACTCTAAA
CGAGATGCTGTGGTGGTGTTGACTATTCGCCATCAACGTGAAGTGGGTTATCAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9967.23 Da
• Isoelectric Point: 6.8690

>AT198880 WP_210225802.1 NZ_CP072800:2269122-2269388 [Candidatus Thiothrix anitrata]
MSVKLDLSDRERLASLAATRNRTSHFLMKQAVQDFLAREEARQAFIADAKASWEHYTQTGLHVTLGELRQWSDTLTANPD
APMPVCHN

Nucleotide

• Length: 267 bp

>AT198880 NZ_CP072800:2269122-2269388 [Candidatus Thiothrix anitrata]
ATGAGCGTCAAGCTTGACCTTAGTGACAGGGAACGCCTTGCATCTTTAGCGGCTACCCGCAACCGCACTTCCCATTTTTT
GATGAAACAGGCAGTGCAGGACTTCTTAGCGCGGGAAGAAGCCCGTCAAGCCTTTATTGCAGATGCTAAAGCCTCTTGGG
AGCATTACACCCAAACGGGGTTGCACGTTACCTTAGGGGAGTTGCGCCAGTGGTCAGATACACTTACGGCTAACCCTGAT
GCGCCGATGCCTGTATGCCACAATTAA