Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 2269122..2269672 Replicon chromosome
Accession NZ_CP072800
Organism Candidatus Thiothrix anitrata isolate A52

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag J8380_RS11675 Protein ID WP_210225803.1
Coordinates 2269376..2269672 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J8380_RS11670 Protein ID WP_210225802.1
Coordinates 2269122..2269388 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8380_RS11650 (J8380_11650) 2265044..2265796 - 753 WP_228292204.1 TSUP family transporter -
J8380_RS11655 (J8380_11655) 2265890..2266906 + 1017 WP_210217591.1 quinone-dependent dihydroorotate dehydrogenase -
J8380_RS11660 (J8380_11660) 2266942..2267751 - 810 WP_210225800.1 hypothetical protein -
J8380_RS11665 (J8380_11665) 2267964..2268983 + 1020 WP_210225801.1 beta-N-acetylhexosaminidase -
J8380_RS11670 (J8380_11670) 2269122..2269388 + 267 WP_210225802.1 ribbon-helix-helix domain-containing protein Antitoxin
J8380_RS11675 (J8380_11675) 2269376..2269672 + 297 WP_210225803.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8380_RS11680 (J8380_11680) 2269769..2270326 + 558 WP_210225804.1 hypoxanthine-guanine phosphoribosyltransferase -
J8380_RS11685 (J8380_11685) 2270328..2271065 + 738 WP_210225805.1 S-methyl-5'-thioinosine phosphorylase -
J8380_RS11690 (J8380_11690) 2271070..2271519 + 450 WP_210225806.1 hypothetical protein -
J8380_RS11695 (J8380_11695) 2271610..2271930 - 321 WP_210225807.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2158658..2311835 153177


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11089.64 Da        Isoelectric Point: 6.7235

>T198880 WP_210225803.1 NZ_CP072800:2269376-2269672 [Candidatus Thiothrix anitrata]
MPQLIISDKARADIVRFHAFLKQQDVTAANNAVFTLLNAFGVLGGQPHIGRLVEDEPDLREFLVEFGNSGYVALYRYDSK
RDAVVVLTIRHQREVGYQ

Download         Length: 297 bp

>T198880 NZ_CP072800:2269376-2269672 [Candidatus Thiothrix anitrata]
ATGCCACAATTAATTATTTCTGATAAAGCGCGGGCAGATATAGTCCGGTTTCATGCCTTTCTGAAACAACAAGATGTGAC
GGCTGCGAATAATGCGGTCTTTACCCTGCTGAATGCTTTTGGTGTCTTGGGGGGGCAGCCACACATCGGGCGGTTGGTGG
AGGATGAACCTGATTTGCGGGAGTTTTTGGTGGAATTTGGTAATAGTGGTTATGTTGCACTGTATCGTTATGACTCTAAA
CGAGATGCTGTGGTGGTGTTGACTATTCGCCATCAACGTGAAGTGGGTTATCAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9967.23 Da        Isoelectric Point: 6.8690

>AT198880 WP_210225802.1 NZ_CP072800:2269122-2269388 [Candidatus Thiothrix anitrata]
MSVKLDLSDRERLASLAATRNRTSHFLMKQAVQDFLAREEARQAFIADAKASWEHYTQTGLHVTLGELRQWSDTLTANPD
APMPVCHN

Download         Length: 267 bp

>AT198880 NZ_CP072800:2269122-2269388 [Candidatus Thiothrix anitrata]
ATGAGCGTCAAGCTTGACCTTAGTGACAGGGAACGCCTTGCATCTTTAGCGGCTACCCGCAACCGCACTTCCCATTTTTT
GATGAAACAGGCAGTGCAGGACTTCTTAGCGCGGGAAGAAGCCCGTCAAGCCTTTATTGCAGATGCTAAAGCCTCTTGGG
AGCATTACACCCAAACGGGGTTGCACGTTACCTTAGGGGAGTTGCGCCAGTGGTCAGATACACTTACGGCTAACCCTGAT
GCGCCGATGCCTGTATGCCACAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References