Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 2022386..2022957 Replicon chromosome
Accession NZ_CP072800
Organism Candidatus Thiothrix anitrata isolate A52

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J8380_RS10460 Protein ID WP_210225599.1
Coordinates 2022386..2022757 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J8380_RS10465 Protein ID WP_210225600.1
Coordinates 2022754..2022957 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8380_RS10430 (J8380_10430) 2018024..2018323 - 300 WP_210225594.1 YciI family protein -
J8380_RS10435 (J8380_10435) 2018388..2019014 + 627 WP_210225595.1 L-threonylcarbamoyladenylate synthase -
J8380_RS10440 (J8380_10440) 2019017..2019673 + 657 WP_210225596.1 site-2 protease family protein -
J8380_RS10445 (J8380_10445) 2019707..2020927 + 1221 WP_210225597.1 tryptophan--tRNA ligase -
J8380_RS10450 (J8380_10450) 2020927..2021733 + 807 WP_210230667.1 segregation/condensation protein A -
J8380_RS10455 (J8380_10455) 2021724..2022296 - 573 WP_210225598.1 hypothetical protein -
J8380_RS10460 (J8380_10460) 2022386..2022757 - 372 WP_210225599.1 type II toxin-antitoxin system VapC family toxin Toxin
J8380_RS10465 (J8380_10465) 2022754..2022957 - 204 WP_210225600.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J8380_RS10470 (J8380_10470) 2023100..2024956 + 1857 WP_228292189.1 site-specific DNA-methyltransferase -
J8380_RS10475 (J8380_10475) 2024959..2027433 + 2475 WP_210225601.1 DEAD/DEAH box helicase family protein -
J8380_RS10480 (J8380_10480) 2027460..2027648 + 189 WP_210225602.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14146.73 Da        Isoelectric Point: 7.7544

>T198879 WP_210225599.1 NZ_CP072800:c2022757-2022386 [Candidatus Thiothrix anitrata]
MILVDTSVWIDHLRVKEERLTMLLGEVQVCMHPMVWGELACGNLKNRPTLLRLWQGLPVLKQATHTETMYCLEQRKLMGK
GIGYVDLHLLTAVLLSPGTQLWTRDKRLRDIAIELGCGWQESH

Download         Length: 372 bp

>T198879 NZ_CP097042:c2657084-2656743 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACTCATGGGCAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7589.70 Da        Isoelectric Point: 5.1106

>AT198879 WP_210225600.1 NZ_CP072800:c2022957-2022754 [Candidatus Thiothrix anitrata]
MRTTLNLDDDLLRQAFELTGITEKAALLRESLKALIERESSRRLALLGGSEPQLETPPRRRITEEAV

Download         Length: 204 bp

>AT198879 NZ_CP097042:c2657314-2657084 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAGCTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGACGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References