Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1799312..1799988 Replicon chromosome
Accession NZ_CP072800
Organism Candidatus Thiothrix anitrata isolate A52

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J8380_RS09390 Protein ID WP_210225419.1
Coordinates 1799545..1799988 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J8380_RS09385 Protein ID WP_210225418.1
Coordinates 1799312..1799545 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8380_RS09370 (J8380_09370) 1795512..1795949 + 438 WP_210219588.1 thioredoxin TrxC -
J8380_RS09375 (J8380_09375) 1796034..1797875 - 1842 WP_210225416.1 ATP-binding protein -
J8380_RS09380 (J8380_09380) 1797889..1799088 - 1200 WP_210225417.1 FIST N-terminal domain-containing protein -
J8380_RS09385 (J8380_09385) 1799312..1799545 + 234 WP_210225418.1 DNA-binding protein Antitoxin
J8380_RS09390 (J8380_09390) 1799545..1799988 + 444 WP_210225419.1 type II toxin-antitoxin system VapC family toxin Toxin
J8380_RS09395 (J8380_09395) 1800075..1801502 - 1428 WP_228292450.1 NAD-dependent succinate-semialdehyde dehydrogenase -
J8380_RS18315 1801648..1802232 + 585 WP_266097268.1 YbfB/YjiJ family MFS transporter -
J8380_RS18320 1802232..1802759 + 528 WP_266097269.1 YbfB/YjiJ family MFS transporter -
J8380_RS09405 (J8380_09405) 1802859..1803095 + 237 WP_210219598.1 50S ribosomal protein L28 -
J8380_RS09410 (J8380_09410) 1803115..1803285 + 171 WP_210225420.1 50S ribosomal protein L33 -
J8380_RS09415 (J8380_09415) 1803367..1803855 + 489 WP_210225421.1 SRPBCC family protein -
J8380_RS09420 (J8380_09420) 1803828..1804343 - 516 WP_210225422.1 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase -
J8380_RS09425 (J8380_09425) 1804325..1804696 - 372 WP_210225423.1 dihydroneopterin aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cap8E / bplB / bplA / ugd 1696243..1903503 207260


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16824.13 Da        Isoelectric Point: 6.0915

>T198878 WP_210225419.1 NZ_CP072800:1799545-1799988 [Candidatus Thiothrix anitrata]
MYLLDTNVISELRKKERMNPGVARFVTQAQAQGSVCYLSVITLGELRRGIDLIYHRGDQEQATILERWLTTVLEEYSEQI
LDFGREEAQLWGHLRVPHPENALDKQIAATALIHDLILVTRNTKDFQSTRVKLYNPFDTTTSPPTPS

Download         Length: 444 bp

>T198878 NZ_CP097042:c2584246-2584094 [Enterococcus faecalis]
GTGGTGCGTATGAGCGCACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCT
AGGGTTTGGTATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAAAAAAAAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8691.06 Da        Isoelectric Point: 7.2042

>AT198878 WP_210225418.1 NZ_CP072800:1799312-1799545 [Candidatus Thiothrix anitrata]
MANLIVRNISDEIAQALKIHASRMGISAEAAHRQILEQVLMRPKKKSFLDLLKEMPNVGRDSDFERIQTDAAPEVFS

Download         Length: 234 bp

>AT198878 NZ_CP097042:2583975-2584161 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGAGTCAACATACCTCTCTAGTGTAGAGCCGTTTGAGACGGTGACCGATT
GTATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTTTTGTCATTTTTAAGCAATTTCACAATCAGTG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References