Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-ChpS
Location 1703417..1704012 Replicon chromosome
Accession NZ_CP072800
Organism Candidatus Thiothrix anitrata isolate A52

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag J8380_RS08885 Protein ID WP_228292417.1
Coordinates 1703674..1704012 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag J8380_RS08880 Protein ID WP_210230269.1
Coordinates 1703417..1703674 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8380_RS08855 (J8380_08855) 1699594..1699977 - 384 WP_210230259.1 fluoride efflux transporter CrcB -
J8380_RS08860 (J8380_08860) 1700020..1700421 - 402 WP_210230261.1 hypothetical protein -
J8380_RS08865 (J8380_08865) 1700500..1701666 - 1167 WP_210230263.1 PilT/PilU family type 4a pilus ATPase -
J8380_RS08870 (J8380_08870) 1701772..1702617 + 846 WP_210230265.1 hypothetical protein -
J8380_RS08875 (J8380_08875) 1702621..1703316 + 696 WP_210230267.1 16S rRNA pseudouridine(516) synthase RsuA -
J8380_RS08880 (J8380_08880) 1703417..1703674 + 258 WP_210230269.1 antitoxin Antitoxin
J8380_RS08885 (J8380_08885) 1703674..1704012 + 339 WP_228292417.1 type II toxin-antitoxin system ChpB family toxin Toxin
J8380_RS08890 (J8380_08890) 1704208..1705266 + 1059 WP_210230272.1 porin -
J8380_RS08900 (J8380_08900) 1705602..1705841 + 240 WP_210230276.1 hypothetical protein -
J8380_RS08905 (J8380_08905) 1705958..1706194 + 237 WP_210230277.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
J8380_RS08910 (J8380_08910) 1706198..1706584 + 387 WP_210230279.1 type II toxin-antitoxin system VapC family toxin -
J8380_RS08915 (J8380_08915) 1706884..1707804 + 921 WP_210230281.1 Rpn family recombination-promoting nuclease/putative transposase -
J8380_RS08920 (J8380_08920) 1707801..1708292 + 492 WP_210230283.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cap8E / bplB / bplA / ugd 1696243..1903503 207260


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12387.26 Da        Isoelectric Point: 6.2563

>T198876 WP_228292417.1 NZ_CP072800:1703674-1704012 [Candidatus Thiothrix anitrata]
MRIPERGEIWFTDLNPTLGKEQQGGRPVLVISTKTFNQSGLVLICPVTQGGNQSRFAGFAVSLMNTGTDTQGVIMCNQLR
TIDYAVRKARFVETVPDYIVDEVLARVQAIVE

Download         Length: 339 bp

>T198876 NZ_CP097042:c2505302-2505201 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAACCCTTGTTGCGTTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACAATAAAAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9254.75 Da        Isoelectric Point: 4.9501

>AT198876 WP_210230269.1 NZ_CP072800:1703417-1703674 [Candidatus Thiothrix anitrata]
MTTATLRAVGGSVVMAIPKRVLELLGLHAGSQVNVNVQNGQLVIVPRVKPRYALGELMAQCDFSQPISQEEREWLDVTPV
GLEDI

Download         Length: 258 bp

>AT198876 NZ_CP097042:2505078-2505264 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAACGCAACAAGGGTTGCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References