Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 1675520..1676280 Replicon chromosome
Accession NZ_CP072800
Organism Candidatus Thiothrix anitrata isolate A52

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag J8380_RS08670 Protein ID WP_228292415.1
Coordinates 1675520..1675906 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag J8380_RS08675 Protein ID WP_210230192.1
Coordinates 1675996..1676280 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8380_RS08640 (J8380_08640) 1671156..1672514 + 1359 WP_210230180.1 DUF853 family protein -
J8380_RS08645 (J8380_08645) 1672551..1672793 + 243 WP_210230182.1 hypothetical protein -
J8380_RS08650 (J8380_08650) 1672771..1673685 + 915 WP_210230184.1 hypothetical protein -
J8380_RS08655 (J8380_08655) 1673690..1673926 + 237 WP_210230186.1 hypothetical protein -
J8380_RS08660 (J8380_08660) 1674096..1674566 + 471 WP_210230188.1 hypothetical protein -
J8380_RS08665 (J8380_08665) 1674550..1675482 - 933 WP_210230190.1 hypothetical protein -
J8380_RS08670 (J8380_08670) 1675520..1675906 - 387 WP_228292415.1 GNAT family N-acetyltransferase Toxin
J8380_RS08675 (J8380_08675) 1675996..1676280 - 285 WP_210230192.1 DUF1778 domain-containing protein Antitoxin
J8380_RS08680 (J8380_08680) 1676404..1677849 - 1446 WP_210230194.1 DUF87 domain-containing protein -
J8380_RS08685 (J8380_08685) 1677854..1678924 - 1071 WP_210230196.1 hypothetical protein -
J8380_RS08690 (J8380_08690) 1678935..1680215 - 1281 WP_210230198.1 TIGR02594 family protein -
J8380_RS08695 (J8380_08695) 1680212..1680412 - 201 WP_210230205.1 hypothetical protein -
J8380_RS08700 (J8380_08700) 1680439..1680966 - 528 WP_210225858.1 hypothetical protein -
J8380_RS08705 (J8380_08705) 1680963..1681217 - 255 WP_210225859.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1620348..1695061 74713


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(10-111)

Antitoxin

Vibrio phage ICP1, Orf50

(11-87)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13870.27 Da        Isoelectric Point: 9.4417

>T198875 WP_228292415.1 NZ_CP072800:c1675906-1675520 [Candidatus Thiothrix anitrata]
MKNEAAGASRTYVVCDGLQVVGYYALATGSAMLDAAPGKIRRNMPDPIPLIILGRLATDVRYQGQGLGRGLLKDALLRSL
QVAQQVGVRALLVHALSEQAKQFYLHHGFVESPLDEMKLFLPLQGLVV

Download         Length: 387 bp

>T198875 NZ_CP097042:c312605-312510 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGCTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10776.41 Da        Isoelectric Point: 6.4558

>AT198875 WP_210230192.1 NZ_CP072800:c1676280-1675996 [Candidatus Thiothrix anitrata]
MQTTPNRDSPINLRALPTQRLLIDKAATLLGKSRSDFMLEVACREAMDVLLDQRLFLLDEQQFHAFDAALSTPLSVDQQQ
RISKLLRTPSLWEH

Download         Length: 285 bp

>AT198875 NZ_CP097042:312411-312475 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGCAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References