Detailed information of TA system TA198873

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 466028..466575
• Replicon: chromosome
• Accession: NZ_CP072800
• Organism: Candidatus Thiothrix anitrata isolate A52

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: J8380_RS02310
• Protein ID: WP_210227969.1
• Coordinates: 466028..466327 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: J8380_RS02315
• Protein ID: WP_210227971.1
• Coordinates: 466327..466575 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8380_RS02295 (J8380_02295)	461292..463466	+	2175	WP_210227964.1	malate synthase G	-
J8380_RS02300 (J8380_02300)	463582..464112	-	531	WP_210227966.1	anti-sigma factor	-
J8380_RS02305 (J8380_02305)	464234..465952	+	1719	WP_210227967.1	30S ribosomal protein S12 methylthiotransferase accessory factor YcaO	-
J8380_RS02310 (J8380_02310)	466028..466327	-	300	WP_210227969.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J8380_RS02315 (J8380_02315)	466327..466575	-	249	WP_210227971.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
J8380_RS02320 (J8380_02320)	466760..467884	+	1125	WP_210227973.1	ATP-binding protein	-
J8380_RS02325 (J8380_02325)	467903..468226	-	324	WP_210227975.1	XRE family transcriptional regulator	-
J8380_RS02330 (J8380_02330)	468268..469047	-	780	WP_210227977.1	hydroxymethylpyrimidine/phosphomethylpyrimidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-91)

Antitoxin

• Antitoxin ParD (1-77)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11225.76 Da
• Isoelectric Point: 6.9875

>T198873 WP_210227969.1 NZ_CP072800:c466327-466028 [Candidatus Thiothrix anitrata]
MAHSLSPLAVEDLKGIWRYGTATWGLTKAEQYGEKLLDAFDFLAENPNAGQPINHIRTGYKRYPVGAHLIFYRLGLSSSV
EIIRILHQSMDSEQHLQDK

Nucleotide

• Length: 300 bp

>T198873 NZ_CP097039:c77362-76499 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGATCAGGTAAAACTAGTTTGCGATCGGCAATTT
CCGAAGAGACACAAGGAAATGTTGTTATCATTGATAATGATACGTTCAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAATACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
AGATAAAGGGTATAATTTAGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGATTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGGTATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGGATTTAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9294.45 Da
• Isoelectric Point: 7.2052

>AT198873 WP_210227971.1 NZ_CP072800:c466575-466327 [Candidatus Thiothrix anitrata]
MSRNTSISLSGHFETFVDRLVSTGSYHSVSEVIRAALRLLEEQELRVQRLREALIAGENSGQPQAFDREAFKREMRAELG
SK

Nucleotide

• Length: 249 bp

>AT198873 NZ_CP097039:c77636-77364 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGACAAAAGAGAAAGTGGCTTAA