Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 6045..6607 Replicon plasmid pTunz4
Accession NZ_CP072799
Organism Thiothrix unzii strain A1

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag J9260_RS18500 Protein ID WP_210220943.1
Coordinates 6045..6347 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J9260_RS18505 Protein ID WP_202719288.1
Coordinates 6335..6607 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9260_RS18465 (J9260_18460) 1726..2868 + 1143 WP_246499851.1 replication initiation protein -
J9260_RS18470 (J9260_18465) 2965..3279 + 315 WP_210220937.1 hypothetical protein -
J9260_RS18475 (J9260_18470) 3653..3856 + 204 WP_210220938.1 DUF2158 domain-containing protein -
J9260_RS18480 (J9260_18475) 3856..4122 + 267 WP_210220939.1 hypothetical protein -
J9260_RS18485 (J9260_18480) 4198..4848 - 651 WP_210220940.1 DUF3800 domain-containing protein -
J9260_RS18490 (J9260_18485) 5020..5262 - 243 WP_210220941.1 ribbon-helix-helix domain-containing protein -
J9260_RS18495 (J9260_18490) 5313..5954 - 642 WP_210220942.1 AAA family ATPase -
J9260_RS18500 (J9260_18495) 6045..6347 - 303 WP_210220943.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9260_RS18505 (J9260_18500) 6335..6607 - 273 WP_202719288.1 CopG family ribbon-helix-helix protein Antitoxin
J9260_RS18510 (J9260_18505) 6733..7038 - 306 WP_210220944.1 hypothetical protein -
J9260_RS18515 (J9260_18510) 7433..7795 + 363 WP_210220945.1 DUF2513 domain-containing protein -
J9260_RS18520 (J9260_18515) 7922..8881 + 960 WP_210220946.1 HEPN domain-containing protein -
J9260_RS18525 (J9260_18520) 8979..9650 + 672 WP_210220947.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..18228 18228
- inside Integron - - 3..18227 18224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-93)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11342.14 Da        Isoelectric Point: 8.5314

>T198871 WP_210220943.1 NZ_CP072799:c6347-6045 [Thiothrix unzii]
MPSLIFSHTALLDLERLRAFLRAKNLPAARRAVVKIMQGLQALEQHPELGHTVEDRPEDYRELVIPFGKDGYIAAYRYAG
DSLVVLGVRHQRELQPPTLP

Download         Length: 303 bp

>T198871 NZ_CP097038:2718213-2718356 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTAAAAGAAAACAATAAAAAATAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10848.12 Da        Isoelectric Point: 5.5623

>AT198871 WP_202719288.1 NZ_CP072799:c6607-6335 [Thiothrix unzii]
MPTSIKLDMDTKTRLQRLATSRQRSTHWLMQEAIRQYLEREEQLAQFRDEMQTAWDDYQDTGLHVTGKEVFAWMETWFTD
SEAQTPKCHH

Download         Length: 273 bp

>AT198871 NZ_CP097038:c2718550-2718288 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGACAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTTTTCTTTTACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References