Detailed information of TA system TA198868

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 2158510..2159096
• Replicon: chromosome
• Accession: NZ_CP072793
• Organism: Thiothrix unzii strain A1

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: J9260_RS10680
• Protein ID: WP_210217763.1
• Coordinates: 2158788..2159096 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J9260_RS10675
• Protein ID: WP_210217762.1
• Coordinates: 2158510..2158791 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9260_RS10655 (J9260_10650)	2154836..2155591	+	756	WP_210217758.1	molybdopterin-synthase adenylyltransferase MoeB	-
J9260_RS10660 (J9260_10655)	2155571..2156338	-	768	WP_210217759.1	fumarylacetoacetate hydrolase family protein	-
J9260_RS10665 (J9260_10660)	2156624..2157577	-	954	WP_210217760.1	transcriptional regulator GcvA	-
J9260_RS10670 (J9260_10665)	2157661..2158413	+	753	WP_210217761.1	DUF4143 domain-containing protein	-
J9260_RS10675 (J9260_10670)	2158510..2158791	-	282	WP_210217762.1	putative addiction module antidote protein	Antitoxin
J9260_RS10680 (J9260_10675)	2158788..2159096	-	309	WP_210217763.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
J9260_RS10685 (J9260_10680)	2159223..2159903	-	681	WP_210217764.1	transposase	-
J9260_RS10690 (J9260_10685)	2160173..2160451	-	279	WP_210217765.1	hypothetical protein	-
J9260_RS10695 (J9260_10690)	2160613..2161149	-	537	WP_210217766.1	hypothetical protein	-
J9260_RS10700 (J9260_10695)	2161362..2162387	-	1026	WP_210217767.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-96)

Antitoxin

• Uncharacterized protein HI1420 (4-90)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11531.21 Da
• Isoelectric Point: 9.4458

>T198868 WP_210217763.1 NZ_CP072793:c2159096-2158788 [Thiothrix unzii]
MNIILKSDKFDDWLSNLRDKKAKAKIALRLGRAEQGNFGDCEPVGEGVSEMRIHYGPGYRLYFTRRGDVVYLLLLGGDKS
TQQTDIKRAIEMANNLPKESTP

Nucleotide

• Length: 309 bp

>T198868 NZ_CP097038:c2568529-2568428 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAACCCTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACAATAAAAAATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10225.71 Da
• Isoelectric Point: 4.8102

>AT198868 WP_210217762.1 NZ_CP072793:c2158791-2158510 [Thiothrix unzii]
MTKFTPFDAADYLDDEETIAAYLSEALEDPDPDTFLMAVRTVARARGMTQLAKDSGLGRESLYKALTPGAKPRYDTMMKV
IRALGIKLHAEAA

Nucleotide

• Length: 282 bp

>AT198868 NZ_CP097038:2568310-2568491 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAAT
CAGTAGTGCAACAAGGGTTGCA