Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PumA-relB/upstrm_HI1419-dnstrm_HI1420 |
| Location | 2018315..2018943 | Replicon | chromosome |
| Accession | NZ_CP072793 | ||
| Organism | Thiothrix unzii strain A1 | ||
Toxin (Protein)
| Gene name | PumA | Uniprot ID | - |
| Locus tag | J9260_RS10105 | Protein ID | WP_210217665.1 |
| Coordinates | 2018315..2018620 (+) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | J9260_RS10110 | Protein ID | WP_210217666.1 |
| Coordinates | 2018617..2018943 (+) | Length | 109 a.a. |
Genomic Context
Location: 2016017..2018113 (2097 bp)
Type: Others
Protein ID: WP_210217664.1
Type: Others
Protein ID: WP_210217664.1
Location: 2018315..2018620 (306 bp)
Type: Toxin
Protein ID: WP_210217665.1
Type: Toxin
Protein ID: WP_210217665.1
Location: 2018617..2018943 (327 bp)
Type: Antitoxin
Protein ID: WP_210217666.1
Type: Antitoxin
Protein ID: WP_210217666.1
Location: 2018940..2020040 (1101 bp)
Type: Others
Protein ID: WP_246499383.1
Type: Others
Protein ID: WP_246499383.1
Location: 2020170..2021843 (1674 bp)
Type: Others
Protein ID: WP_210217667.1
Type: Others
Protein ID: WP_210217667.1
Location: 2013559..2014917 (1359 bp)
Type: Others
Protein ID: WP_210217663.1
Type: Others
Protein ID: WP_210217663.1
Location: 2014977..2015966 (990 bp)
Type: Others
Protein ID: WP_246499381.1
Type: Others
Protein ID: WP_246499381.1
Location: 2021823..2022275 (453 bp)
Type: Others
Protein ID: WP_246499762.1
Type: Others
Protein ID: WP_246499762.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J9260_RS10085 (J9260_10080) | 2013559..2014917 | - | 1359 | WP_210217663.1 | MFS transporter | - |
| J9260_RS10090 (J9260_10085) | 2014977..2015966 | - | 990 | WP_246499381.1 | DUF523 and DUF1722 domain-containing protein | - |
| J9260_RS10095 (J9260_10090) | 2016017..2018113 | + | 2097 | WP_210217664.1 | mechanosensitive ion channel | - |
| J9260_RS10105 (J9260_10100) | 2018315..2018620 | + | 306 | WP_210217665.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J9260_RS10110 (J9260_10105) | 2018617..2018943 | + | 327 | WP_210217666.1 | putative addiction module antidote protein | Antitoxin |
| J9260_RS10115 (J9260_10110) | 2018940..2020040 | + | 1101 | WP_246499383.1 | spermidine/putrescine ABC transporter ATP-binding protein PotA | - |
| J9260_RS10120 (J9260_10115) | 2020170..2021843 | + | 1674 | WP_210217667.1 | hypothetical protein | - |
| J9260_RS10125 (J9260_10120) | 2021823..2022275 | - | 453 | WP_246499762.1 | tRNA adenosine(34) deaminase TadA | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11458.14 Da Isoelectric Point: 8.9203
>T198866 WP_210217665.1 NZ_CP072793:2018315-2018620 [Thiothrix unzii]
MIEIIQSKVFSDWLLGLKDRQARARIYARLDRMADGNFGDAEPIGEGMSEARIHYGPGYRLYFMQRGQALVVLLCGGDKS
TQQRDIQRAKVVADLWKGENP
MIEIIQSKVFSDWLLGLKDRQARARIYARLDRMADGNFGDAEPIGEGMSEARIHYGPGYRLYFMQRGQALVVLLCGGDKS
TQQRDIQRAKVVADLWKGENP
Download Length: 306 bp
>T198866 NZ_CP097038:469955-470071 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA
Antitoxin
Download Length: 109 a.a. Molecular weight: 11842.44 Da Isoelectric Point: 4.8231
>AT198866 WP_210217666.1 NZ_CP072793:2018617-2018943 [Thiothrix unzii]
MSTTFSRYDTAAYLKTDEDMQDYLEACMEEAGDDPQFIAKALGVIARARGMSQLARDSGLARESLYKALSGEGNPEFSTI
LKVINAMGLRLHFSLRDTAPTLSTVKLS
MSTTFSRYDTAAYLKTDEDMQDYLEACMEEAGDDPQFIAKALGVIARARGMSQLARDSGLARESLYKALSGEGNPEFSTI
LKVINAMGLRLHFSLRDTAPTLSTVKLS
Download Length: 327 bp
>AT198866 NZ_CP097038:c470187-469982 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC