Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 2018315..2018943 Replicon chromosome
Accession NZ_CP072793
Organism Thiothrix unzii strain A1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag J9260_RS10105 Protein ID WP_210217665.1
Coordinates 2018315..2018620 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J9260_RS10110 Protein ID WP_210217666.1
Coordinates 2018617..2018943 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J9260_RS10085 (J9260_10080) 2013559..2014917 - 1359 WP_210217663.1 MFS transporter -
J9260_RS10090 (J9260_10085) 2014977..2015966 - 990 WP_246499381.1 DUF523 and DUF1722 domain-containing protein -
J9260_RS10095 (J9260_10090) 2016017..2018113 + 2097 WP_210217664.1 mechanosensitive ion channel -
J9260_RS10105 (J9260_10100) 2018315..2018620 + 306 WP_210217665.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J9260_RS10110 (J9260_10105) 2018617..2018943 + 327 WP_210217666.1 putative addiction module antidote protein Antitoxin
J9260_RS10115 (J9260_10110) 2018940..2020040 + 1101 WP_246499383.1 spermidine/putrescine ABC transporter ATP-binding protein PotA -
J9260_RS10120 (J9260_10115) 2020170..2021843 + 1674 WP_210217667.1 hypothetical protein -
J9260_RS10125 (J9260_10120) 2021823..2022275 - 453 WP_246499762.1 tRNA adenosine(34) deaminase TadA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-91)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11458.14 Da        Isoelectric Point: 8.9203

>T198866 WP_210217665.1 NZ_CP072793:2018315-2018620 [Thiothrix unzii]
MIEIIQSKVFSDWLLGLKDRQARARIYARLDRMADGNFGDAEPIGEGMSEARIHYGPGYRLYFMQRGQALVVLLCGGDKS
TQQRDIQRAKVVADLWKGENP

Download         Length: 306 bp

>T198866 NZ_CP097038:469955-470071 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11842.44 Da        Isoelectric Point: 4.8231

>AT198866 WP_210217666.1 NZ_CP072793:2018617-2018943 [Thiothrix unzii]
MSTTFSRYDTAAYLKTDEDMQDYLEACMEEAGDDPQFIAKALGVIARARGMSQLARDSGLARESLYKALSGEGNPEFSTI
LKVINAMGLRLHFSLRDTAPTLSTVKLS

Download         Length: 327 bp

>AT198866 NZ_CP097038:c470187-469982 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References