Detailed information of TA system TA198864

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 1295630..1296654
• Replicon: chromosome
• Accession: NZ_CP072793
• Organism: Thiothrix unzii strain A1

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: J9260_RS06675
• Protein ID: WP_210220242.1
• Coordinates: 1295630..1296208 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: J9260_RS06680
• Protein ID: WP_210220243.1
• Coordinates: 1296208..1296654 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9260_RS06640 (J9260_06635)	1291157..1292407	-	1251	WP_210220235.1	TIGR02594 family protein	-
J9260_RS06645 (J9260_06640)	1292404..1292607	-	204	WP_210220236.1	hypothetical protein	-
J9260_RS06650 (J9260_06645)	1292634..1293161	-	528	WP_210220237.1	hypothetical protein	-
J9260_RS06655 (J9260_06650)	1293158..1293400	-	243	WP_210220238.1	hypothetical protein	-
J9260_RS06660 (J9260_06655)	1293557..1294819	-	1263	WP_210220239.1	hypothetical protein	-
J9260_RS06665 (J9260_06660)	1294978..1295217	-	240	WP_210220240.1	hypothetical protein	-
J9260_RS06670 (J9260_06665)	1295309..1295605	+	297	WP_210220241.1	helix-turn-helix transcriptional regulator	-
J9260_RS06675 (J9260_06670)	1295630..1296208	-	579	WP_210220242.1	PIN domain-containing protein	Toxin
J9260_RS06680 (J9260_06675)	1296208..1296654	-	447	WP_210220243.1	helix-turn-helix domain-containing protein	Antitoxin
J9260_RS06685 (J9260_06680)	1296878..1297090	+	213	WP_210220244.1	hypothetical protein	-
J9260_RS06690 (J9260_06685)	1297087..1297260	+	174	WP_210220245.1	hypothetical protein	-
J9260_RS06695 (J9260_06690)	1297285..1297509	+	225	WP_210220246.1	hypothetical protein	-
J9260_RS06700 (J9260_06695)	1297512..1297805	+	294	WP_210220247.1	hypothetical protein	-
J9260_RS06705 (J9260_06700)	1297946..1299103	+	1158	WP_210220248.1	hypothetical protein	-
J9260_RS06715 (J9260_06710)	1299453..1301327	-	1875	WP_210220249.1	RNA polymerase sigma factor RpoD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-116)

Antitoxin

• Helix-turn-helix domain, group 17 (78-126)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21893.44 Da
• Isoelectric Point: 7.8976

>T198864 WP_210220242.1 NZ_CP072793:c1296208-1295630 [Thiothrix unzii]
MLSGQNFTVLYDACVLYPAPLRDFLVRLAWTGVFRAKWTQQIHEEWICNALQNNTKLTRERLEMTAGKMNAAIMDSLVSG
YEPLIAGLELPDVNDRHVLAAAIKGQAEVIVTFNLKDFPASYLKPFGILAQHPDEFISHLTNLYPEMILLTARQQRASLK
NPPRTVDEFLDTLLRQQLPRTAAFLKQRKELI

Nucleotide

• Length: 579 bp

>T198864 NZ_CP097037:c24968-24627 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGTTGGAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACAATGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCCACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGATTTTACAGAAAGAAAGTTAAGCCAAATAGAACATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16580.24 Da
• Isoelectric Point: 5.2767

>AT198864 WP_210220243.1 NZ_CP072793:c1296654-1296208 [Thiothrix unzii]
MPALVSYQVPTQEDTELAVESSRLLAACIGKGESACLRLHNGNELLQVPVKAIRLLVDILDAMARGDAVSLIPIHKELTT
QEAANILNVSRPYLVKLIEAGEIPFHKNGVRRRVFFKDLMEYKQKRDQASMLLLDELTAEAQEFEMGY

Nucleotide

• Length: 447 bp

>AT198864 NZ_CP097037:c25198-24968 [Enterococcus faecalis]
ATGTTAACAACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAATGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTGATGTATTCTGATGATGGGACAATTACGTTAGTCCCTAAATTACAAGATCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA