Detailed information of TA system TA198863

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1004038..1004663
• Replicon: chromosome
• Accession: NZ_CP072793
• Organism: Thiothrix unzii strain A1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: J9260_RS05195
• Protein ID: WP_210219975.1
• Coordinates: 1004265..1004663 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: J9260_RS05190
• Protein ID: WP_210219974.1
• Coordinates: 1004038..1004265 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9260_RS05170 (J9260_05165)	999290..1001260	+	1971	WP_246499642.1	EAL domain-containing protein	-
J9260_RS05175 (J9260_05170)	1001351..1001821	+	471	WP_210219972.1	FxsA family protein	-
J9260_RS05180 (J9260_05175)	1001920..1002210	+	291	WP_093069816.1	co-chaperone GroES	-
J9260_RS05185 (J9260_05180)	1002230..1003867	+	1638	WP_210219973.1	chaperonin GroEL	-
J9260_RS05190 (J9260_05185)	1004038..1004265	+	228	WP_210219974.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
J9260_RS05195 (J9260_05190)	1004265..1004663	+	399	WP_210219975.1	type II toxin-antitoxin system VapC family toxin	Toxin
J9260_RS05200 (J9260_05195)	1004791..1005069	-	279	WP_210219976.1	hypothetical protein	-
J9260_RS05205 (J9260_05200)	1005332..1006267	-	936	WP_210219977.1	2OG-Fe(II) oxygenase family protein	-
J9260_RS05210 (J9260_05205)	1006381..1007079	+	699	WP_210219978.1	Crp/Fnr family transcriptional regulator	-
J9260_RS05215 (J9260_05210)	1007248..1008849	+	1602	WP_210219979.1	cytochrome ubiquinol oxidase subunit I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• SpoVT-AbrB domain (7-49)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14911.40 Da
• Isoelectric Point: 9.3779

>T198863 WP_210219975.1 NZ_CP072793:1004265-1004663 [Thiothrix unzii]
MKYLLDTNICIYLIKEKPPEVLLRFTALKPAQVFISAVTVFELYYGVENSQAHKRNLAALEKFLRPMTILDFTPEDAKQA
ARIRADLKRKGTPIGAYDLQIAATALANGLTVVTNNTDEFQRVVGLRLENWV

Nucleotide

• Length: 399 bp

>T198863 NZ_CP097035:c35598-34735 [Enterococcus faecalis]
ATGGCGAATATTACTGACTTCACCGAAAAGCAATTTGAAGATCGTTTAGAAAAGAATGTTGAACGACTAACTAAAAATAG
ACTAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCAAATTTTGACGAATTAGTG
AAACTCTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCGAATCGCATGACAGAAGCACTTATTAGCCGTTTAAG
CGATCAAGGCTATAATTTAGTGATTGAAGGAACAGGACGAACAACAGACGTTCCCATTCAAACAGCCACAATGCTTCAAT
CTAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGGTATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GCTTAGAAACGCCTTCCATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGGTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGGATTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8818.99 Da
• Isoelectric Point: 6.3084

>AT198863 WP_210219974.1 NZ_CP072793:1004038-1004265 [Thiothrix unzii]
MQTAKIFQNGRSQAIRLPKAFRLSGTEVRISREGNRIILEPLKQSWDDWLLAIEQFSDDFMAQGREQPAVQEREW

Nucleotide

• Length: 228 bp

>AT198863 NZ_CP097035:c35872-35600 [Enterococcus faecalis]
ATGGCAGTTACGTATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGGGTATTAAA
TTATGTTTTGAATCATGAACTAGATACTAAAAATACTCGTTTACTAGAAGTGAATCTTTTAAATCAATTAGAAGTGGCAC
AAGAAGTTGATTTATTTCAACAACCATTTGAAGAATTACAAGCTATTCATGAGTATTGGCGGTCAATGAATCAATATTCA
AAACAAATTTTGAATAAAGAGAAAGTGGCTTAA