Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3785733..3786400 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag J8397_RS17895 Protein ID WP_003417916.1
Coordinates 3785733..3786125 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0E8U8S7
Locus tag J8397_RS17900 Protein ID WP_003912214.1
Coordinates 3786125..3786400 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS20760 (J8397_17645) 3781105..3782715 - 1611 WP_003417910.1 1-deoxy-D-xylulose-5-phosphate synthase N-terminal domain-containing protein -
J8397_RS20765 3782660..3782941 - 282 WP_003914149.1 1-deoxy-D-xylulose-5-phosphate synthase N-terminal domain-containing protein -
J8397_RS17885 (J8397_17650) 3782938..3783927 - 990 WP_003417912.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
J8397_RS17890 (J8397_17655) 3783927..3784979 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
J8397_RS17895 (J8397_17660) 3785733..3786125 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
J8397_RS17900 (J8397_17665) 3786125..3786400 - 276 WP_003912214.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J8397_RS17905 (J8397_17670) 3786582..3787953 + 1372 Protein_3538 ISNCY family transposase -
J8397_RS17910 (J8397_17675) 3788143..3790347 + 2205 WP_031694772.1 PE family protein -
J8397_RS17915 (J8397_17680) 3790418..3791290 - 873 WP_003417929.1 3-hydroxyacyl-thioester dehydratase HtdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3787276..3787953 677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-53)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T198858 WP_003417916.1 NZ_CP072790:c3786125-3785733 [Mycobacterium tuberculosis]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T198858 NZ_CP097034:467907-468023 [Enterococcus faecalis]
ATGTTTTTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTT
AGCGCTTGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 9966.35 Da        Isoelectric Point: 4.5332

>AT198858 WP_003912214.1 NZ_CP072790:c3786400-3786125 [Mycobacterium tuberculosis]
MTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPS
VTLARLREHER

Download         Length: 276 bp

>AT198858 NZ_CP097034:c468139-467934 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8U8S7

References