Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3758612..3759141 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag J8397_RS17765 Protein ID WP_003417760.1
Coordinates 3758884..3759141 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag J8397_RS17760 Protein ID WP_003417757.1
Coordinates 3758612..3758887 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS17725 3755185..3755874 - 690 WP_003917774.1 BBE domain-containing protein -
J8397_RS17730 3756061..3756432 - 372 WP_003417739.1 FAD-binding protein -
J8397_RS17735 3756330..3756548 - 219 WP_157132559.1 hypothetical protein -
J8397_RS17740 3756575..3756835 - 261 WP_003417741.1 hypothetical protein -
J8397_RS17745 (J8397_17520) 3756950..3757339 + 390 WP_003417745.1 DUF732 domain-containing protein -
J8397_RS17750 (J8397_17525) 3757353..3757646 - 294 WP_003417749.1 DUF3017 domain-containing protein -
J8397_RS17755 (J8397_17530) 3757643..3758488 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
J8397_RS17760 (J8397_17535) 3758612..3758887 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
J8397_RS17765 (J8397_17540) 3758884..3759141 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
J8397_RS17770 (J8397_17545) 3759183..3760373 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
J8397_RS17775 (J8397_17550) 3760490..3760858 + 369 WP_003417765.1 FHA domain-containing protein -
J8397_RS17780 (J8397_17555) 3760855..3761406 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
J8397_RS17785 (J8397_17560) 3761413..3761994 - 582 WP_003417769.1 ATP/GTP-binding protein -
J8397_RS17790 (J8397_17565) 3761975..3762343 - 369 WP_003417772.1 DUF742 domain-containing protein -
J8397_RS17795 (J8397_17570) 3762321..3762713 - 393 WP_003417776.1 serine protease inhibitor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T198857 WP_003417760.1 NZ_CP072790:3758884-3759141 [Mycobacterium tuberculosis]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T198857 NZ_CP097034:c300284-300189 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT198857 WP_003417757.1 NZ_CP072790:3758612-3758887 [Mycobacterium tuberculosis]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT198857 NZ_CP097034:300089-300154 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References