Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3170449..3170997 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag J8397_RS15155 Protein ID WP_003414602.1
Coordinates 3170734..3170997 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag J8397_RS15150 Protein ID WP_003414599.1
Coordinates 3170449..3170730 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS15125 (J8397_14940) 3166072..3166929 - 858 WP_003899513.1 type I methionyl aminopeptidase -
J8397_RS15130 (J8397_14945) 3166971..3167555 - 585 WP_003899514.1 DUF1707 domain-containing protein -
J8397_RS15135 (J8397_14950) 3167659..3167907 + 249 WP_003913411.1 antitoxin VapB23 -
J8397_RS15140 (J8397_14955) 3167904..3168284 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
J8397_RS15145 (J8397_14960) 3168366..3170177 - 1812 WP_003414596.1 penicillin-binding protein -
J8397_RS15150 (J8397_14965) 3170449..3170730 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
J8397_RS15155 (J8397_14970) 3170734..3170997 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8397_RS15160 (J8397_14975) 3171370..3172224 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
J8397_RS15165 (J8397_14980) 3172280..3173443 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
J8397_RS15170 (J8397_14985) 3173460..3174674 - 1215 WP_003899518.1 zinc metalloprotease Rip -
J8397_RS15175 (J8397_14990) 3174682..3175923 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T198853 WP_003414602.1 NZ_CP072790:3170734-3170997 [Mycobacterium tuberculosis]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T198853 NZ_CP097031:2660733-2660876 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCGACTTTAATCTTCGGAATCCTAAAGGTTGTTAAAGAAGACAAGAAAAAATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT198853 WP_003414599.1 NZ_CP072790:3170449-3170730 [Mycobacterium tuberculosis]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT198853 NZ_CP097031:c2661067-2660808 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGCATTGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACTTTTTGGATTATTT
AAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCTTCTTTAACAACCTTTAGGATTCCGAAGATTAAA
GTCGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References