Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 3104311..3104881 | Replicon | chromosome |
Accession | NZ_CP072790 | ||
Organism | Mycobacterium tuberculosis strain I0003447-5 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | P71650 |
Locus tag | J8397_RS14820 | Protein ID | WP_003414166.1 |
Coordinates | 3104311..3104667 (-) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | P0CL61 |
Locus tag | J8397_RS14825 | Protein ID | WP_003901465.1 |
Coordinates | 3104651..3104881 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
J8397_RS14800 (J8397_14610) | 3099763..3101451 | - | 1689 | WP_003414155.1 | alpha/beta hydrolase family protein | - |
J8397_RS14805 (J8397_14615) | 3101455..3101781 | - | 327 | WP_003414157.1 | hypothetical protein | - |
J8397_RS14810 (J8397_14620) | 3101954..3102541 | + | 588 | WP_003914429.1 | DUF3558 family protein | - |
J8397_RS14815 (J8397_14625) | 3102560..3104209 | + | 1650 | WP_003899485.1 | CocE/NonD family hydrolase | - |
J8397_RS14820 (J8397_14630) | 3104311..3104667 | - | 357 | WP_003414166.1 | type II toxin-antitoxin system toxin endoribonuclease MazF9 | Toxin |
J8397_RS14825 (J8397_14635) | 3104651..3104881 | - | 231 | WP_003901465.1 | type II toxin-antitoxin system antitoxin MazE9 | Antitoxin |
J8397_RS14830 (J8397_14640) | 3104924..3105967 | - | 1044 | WP_003414172.1 | DUF2293 domain-containing protein | - |
J8397_RS14835 | 3105966..3106433 | + | 468 | WP_003414177.1 | DUF1778 domain-containing protein | - |
J8397_RS14840 (J8397_14650) | 3106462..3106716 | - | 255 | WP_003917684.1 | hypothetical protein | - |
J8397_RS14845 (J8397_14655) | 3106864..3107268 | + | 405 | WP_009938577.1 | hypothetical protein | - |
J8397_RS14850 (J8397_14660) | 3107265..3107456 | + | 192 | WP_003414184.1 | hypothetical protein | - |
J8397_RS14855 | 3107673..3107933 | + | 261 | Protein_2932 | transposase | - |
J8397_RS14860 (J8397_14670) | 3109043..3109300 | + | 258 | WP_003899489.1 | hypothetical protein | - |
J8397_RS14865 (J8397_14675) | 3109405..3109716 | + | 312 | WP_003414190.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 3094346..3118512 | 24166 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12858.73 Da Isoelectric Point: 9.1962
>T198850 WP_003414166.1 NZ_CP072790:c3104667-3104311 [Mycobacterium tuberculosis]
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
VMRRGEIWQVDLDPARGSEANNQRPAVVVSNDRANATATRLGRGVITVVPVTSNIAKVYPFQVLLSATTTGLQVDCKAQA
EQIRSIATERLLRPIGRVSAAELAQLDEALKLHLDLWS
Download Length: 357 bp
>T198850 NZ_CP097031:2656085-2656189 [Enterococcus faecalis]
TTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
GCTTAAAAATGACAAGAAAAAATAA
TTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
GCTTAAAAATGACAAGAAAAAATAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8231.01 Da Isoelectric Point: 4.1809
>AT198850 WP_003901465.1 NZ_CP072790:c3104881-3104651 [Mycobacterium tuberculosis]
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
VKLSVSLSDDDVAILDAYVKRAGLPSRSAGLQHAIRVLRYPTLEDDYANAWQEWSAAGDTDAWEQTVGDGVGDAPR
Download Length: 231 bp
>AT198850 NZ_CP097031:c2655945-2655791 [Enterococcus faecalis]
TTTTTAGGTAAGTGTGCTATAATAGCAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGTGGTTTAAGA
CGGTGACCTTTTGGATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCTTCTTTAA
TTTTTAGGTAAGTGTGCTATAATAGCAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGTGGTTTAAGA
CGGTGACCTTTTGGATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCTTCTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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