Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VapB |
| Location | 3064314..3064993 | Replicon | chromosome |
| Accession | NZ_CP072790 | ||
| Organism | Mycobacterium tuberculosis strain I0003447-5 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | P9WF90 |
| Locus tag | J8397_RS14590 | Protein ID | WP_003414059.1 |
| Coordinates | 3064314..3064730 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | G0TF64 |
| Locus tag | J8397_RS14595 | Protein ID | WP_003414061.1 |
| Coordinates | 3064727..3064993 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8397_RS14565 (J8397_14390) | 3060366..3061268 | - | 903 | WP_075911274.1 | 4-hydroxy-tetrahydrodipicolinate synthase | - |
| J8397_RS14570 (J8397_14395) | 3061337..3062089 | - | 753 | WP_003899465.1 | FAD-dependent thymidylate synthase | - |
| J8397_RS14575 | 3062116..3062253 | - | 138 | Protein_2876 | type II toxin-antitoxin system VapC family toxin | - |
| J8397_RS14580 (J8397_14400) | 3062333..3062608 | - | 276 | WP_003414055.1 | type I restriction endonuclease subunit S | - |
| J8397_RS14585 (J8397_14405) | 3062605..3064227 | - | 1623 | WP_003906897.1 | class I SAM-dependent DNA methyltransferase | - |
| J8397_RS14590 (J8397_14410) | 3064314..3064730 | - | 417 | WP_003414059.1 | type II toxin-antitoxin system toxin ribonuclease C21 | Toxin |
| J8397_RS14595 (J8397_14415) | 3064727..3064993 | - | 267 | WP_003414061.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| J8397_RS14600 (J8397_14420) | 3065019..3065414 | - | 396 | WP_003414064.1 | type II toxin-antitoxin system VapC family toxin | - |
| J8397_RS14605 (J8397_14425) | 3065411..3065680 | - | 270 | WP_003414066.1 | type II toxin-antitoxin system VapB family antitoxin | - |
| J8397_RS14610 (J8397_14430) | 3065690..3066784 | - | 1095 | WP_003414068.1 | restriction endonuclease subunit S | - |
| J8397_RS14615 (J8397_14435) | 3066781..3067200 | - | 420 | WP_003414070.1 | winged helix-turn-helix domain-containing protein | - |
| J8397_RS14620 | 3067199..3067273 | + | 75 | Protein_2885 | hypothetical protein | - |
| J8397_RS14625 (J8397_14440) | 3067274..3067753 | - | 480 | WP_003414073.1 | dihydrofolate reductase | - |
| J8397_RS14630 (J8397_14445) | 3067824..3068624 | - | 801 | WP_003911953.1 | thymidylate synthase | - |
| J8397_RS14635 (J8397_14450) | 3068780..3069517 | + | 738 | WP_003414079.1 | dienelactone hydrolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15773.00 Da Isoelectric Point: 7.1294
>T198848 WP_003414059.1 NZ_CP072790:c3064730-3064314 [Mycobacterium tuberculosis]
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
MTTRYLLDKSAAYRAHLPAVRHRLEPLMERGLLARCGITDLEFGVSARSREDHRTLGTYRRDALEYVNTPDTVWVRAWEI
QEALTDKGFHRSVKIPDLIIAAVAEHHGIPVMHYDQDFERIAAITRQPVEWVVAPGTA
Download Length: 417 bp
>T198848 NZ_CP097031:c2583483-2583340 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTACTTAAAAATGACAATAAAAAATAA
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTACTTAAAAATGACAATAAAAAATAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9493.77 Da Isoelectric Point: 7.2783
>AT198848 WP_003414061.1 NZ_CP072790:c3064993-3064727 [Mycobacterium tuberculosis]
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
MHRGYALVVCSPGVTRTMIDIDDDLLARAAKELGTTTKKDTVHAALRAALRASAARSLMNRMAENATGTQDEALVNAMWR
DGHPENTA
Download Length: 267 bp
>AT198848 NZ_CP097031:2583221-2583407 [Enterococcus faecalis]
TGTGCTATAATGAAAATGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAACCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGTAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA
TGTGCTATAATGAAAATGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAACCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGTAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|