Detailed information of TA system TA198847

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/-
• Location: 2970624..2971272
• Replicon: chromosome
• Accession: NZ_CP072790
• Organism: Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: P9WJ12
• Locus tag: J8397_RS14050
• Protein ID: WP_003899414.1
• Coordinates: 2970624..2970947 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: P9WJ10
• Locus tag: J8397_RS14055
• Protein ID: WP_003899415.1
• Coordinates: 2971027..2971272 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8397_RS14020 (J8397_13845)	2965947..2966945	+	999	WP_003900538.1	tyrosine-type recombinase/integrase	-
J8397_RS14025 (J8397_13850)	2966959..2967423	+	465	WP_003900539.1	ParB N-terminal domain-containing protein	-
J8397_RS14030 (J8397_13855)	2967411..2967662	+	252	WP_003908028.1	hypothetical protein	-
J8397_RS14035 (J8397_13860)	2967833..2969272	-	1440	WP_003899411.1	phage major capsid protein	-
J8397_RS14040 (J8397_13865)	2969280..2969813	-	534	WP_003899412.1	HK97 family phage prohead protease	-
J8397_RS14045 (J8397_13870)	2969966..2970457	-	492	WP_003900541.1	phage terminase small subunit P27 family	-
J8397_RS14050 (J8397_13875)	2970624..2970947	-	324	WP_003899414.1	type II toxin-antitoxin system toxin	Toxin
J8397_RS14055 (J8397_13880)	2971027..2971272	-	246	WP_003899415.1	type II toxin-antitoxin system antitoxin	Antitoxin
J8397_RS14060 (J8397_13885)	2971269..2972696	-	1428	WP_070892804.1	DUF3631 domain-containing protein	-
J8397_RS14065 (J8397_13890)	2972698..2973090	-	393	WP_003899417.1	DUF2742 domain-containing protein	-
J8397_RS14070 (J8397_13895)	2973087..2973347	-	261	WP_003899418.1	helix-turn-helix domain-containing protein	-
J8397_RS14075 (J8397_13900)	2973364..2973726	-	363	WP_003900543.1	hypothetical protein	-
J8397_RS14080 (J8397_13905)	2973729..2974856	-	1128	WP_003899420.1	site-specific integrase	-
J8397_RS14085 (J8397_13910)	2975001..2975228	-	228	WP_003899421.1	hypothetical protein	-
J8397_RS14090 (J8397_13915)	2975225..2975614	-	390	WP_003899422.1	hypothetical protein	-
J8397_RS14095 (J8397_13920)	2975520..2975792	+	273	WP_003900544.1	hypothetical protein	-
J8397_RS14100 (J8397_13925)	2975891..2976124	+	234	WP_003413717.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2952968..2974856	21888

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 12359.82 Da
• Isoelectric Point: 8.6717

>T198847 WP_003899414.1 NZ_CP072790:c2970947-2970624 [Mycobacterium tuberculosis]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Nucleotide

• Length: 324 bp

>T198847 NZ_CP097031:c2519495-2519394 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAACCCTTGTTGCGTTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 7697.71 Da
• Isoelectric Point: 4.8565

>AT198847 WP_003899415.1 NZ_CP072790:c2971272-2971027 [Mycobacterium tuberculosis]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Nucleotide

• Length: 246 bp

>AT198847 NZ_CP097031:2519270-2519457 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGTGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAACGCAACAAGGGTTGCA

Structures

Toxin

• AlphaFold DB: A0A045IHC4

Antitoxin

• AlphaFold DB: A0A806JR81