Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2925466..2926180 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag J8397_RS13765 Protein ID WP_003413460.1
Coordinates 2925740..2926180 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag J8397_RS13760 Protein ID WP_003413456.1
Coordinates 2925466..2925753 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS13725 (J8397_13550) 2920888..2921133 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
J8397_RS13730 (J8397_13555) 2921130..2921534 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
J8397_RS13735 (J8397_13560) 2921751..2922371 + 621 WP_003912795.1 DUF4178 domain-containing protein -
J8397_RS13740 (J8397_13565) 2922382..2922876 + 495 WP_003413444.1 DUF2617 family protein -
J8397_RS13745 (J8397_13570) 2922873..2923304 + 432 WP_003899390.1 DUF4247 domain-containing protein -
J8397_RS13750 (J8397_13575) 2923329..2923787 + 459 WP_003413451.1 DUF350 domain-containing protein -
J8397_RS13755 (J8397_13580) 2923784..2925355 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
J8397_RS13760 (J8397_13585) 2925466..2925753 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
J8397_RS13765 (J8397_13590) 2925740..2926180 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
J8397_RS13770 (J8397_13595) 2926201..2926956 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
J8397_RS13775 (J8397_13600) 2927089..2927685 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
J8397_RS13780 (J8397_13605) 2927693..2928538 - 846 WP_003413466.1 acyl-CoA thioesterase II -
J8397_RS13785 (J8397_13610) 2928567..2929466 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
J8397_RS13790 (J8397_13615) 2929594..2930268 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T198846 WP_003413460.1 NZ_CP072790:2925740-2926180 [Mycobacterium tuberculosis]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T198846 NZ_CP097031:c2519061-2518960 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACAATAAAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT198846 WP_003413456.1 NZ_CP072790:2925466-2925753 [Mycobacterium tuberculosis]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT198846 NZ_CP097031:2518841-2519015 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References