Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 2864003..2864634 | Replicon | chromosome |
Accession | NZ_CP072790 | ||
Organism | Mycobacterium tuberculosis strain I0003447-5 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | G0TQ28 |
Locus tag | J8397_RS13490 | Protein ID | WP_003413174.1 |
Coordinates | 2864257..2864634 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | P95006 |
Locus tag | J8397_RS13485 | Protein ID | WP_003413167.1 |
Coordinates | 2864003..2864260 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
J8397_RS13455 (J8397_13280) | 2859917..2860231 | + | 315 | WP_009937839.1 | hypothetical protein | - |
J8397_RS13460 (J8397_13285) | 2860527..2861738 | + | 1212 | WP_003900845.1 | alpha/beta hydrolase family protein | - |
J8397_RS13465 (J8397_13290) | 2861865..2862524 | + | 660 | WP_003900846.1 | LppA family lipoprotein | - |
J8397_RS13470 (J8397_13295) | 2862521..2863183 | + | 663 | WP_003900848.1 | LppA family lipoprotein | - |
J8397_RS13475 (J8397_13300) | 2863180..2863458 | + | 279 | WP_003901422.1 | type II toxin-antitoxin system VapB family antitoxin | - |
J8397_RS13480 (J8397_13305) | 2863551..2863964 | + | 414 | WP_003912787.1 | PIN domain nuclease | - |
J8397_RS13485 (J8397_13310) | 2864003..2864260 | + | 258 | WP_003413167.1 | CopG family transcriptional regulator | Antitoxin |
J8397_RS13490 (J8397_13315) | 2864257..2864634 | + | 378 | WP_003413174.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
J8397_RS13495 (J8397_13320) | 2864650..2865024 | - | 375 | WP_003413177.1 | hypothetical protein | - |
J8397_RS13500 (J8397_13325) | 2865124..2865519 | - | 396 | WP_003413180.1 | type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 | - |
J8397_RS13505 (J8397_13330) | 2865516..2865761 | - | 246 | WP_003413183.1 | type II toxin-antitoxin system antitoxin VapB20 | - |
J8397_RS13510 (J8397_13335) | 2866172..2866591 | - | 420 | WP_003413190.1 | A24 family peptidase | - |
J8397_RS13515 (J8397_13340) | 2866603..2867412 | - | 810 | WP_003413193.1 | shikimate dehydrogenase | - |
J8397_RS13520 (J8397_13345) | 2867409..2868662 | - | 1254 | WP_003413196.1 | endolytic transglycosylase MltG | - |
J8397_RS13525 (J8397_13350) | 2868655..2869167 | - | 513 | WP_003413197.1 | Holliday junction resolvase RuvX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13728.72 Da Isoelectric Point: 4.4687
>T198844 WP_003413174.1 NZ_CP072790:2864257-2864634 [Mycobacterium tuberculosis]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY
Download Length: 378 bp
>T198844 NZ_CP097031:c303817-303722 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCTATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA
ATGTACGAGATTGTCACAAAAATTCTTGTGCCTATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9453.63 Da Isoelectric Point: 10.6555
>AT198844 WP_003413167.1 NZ_CP072790:2864003-2864260 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA
Download Length: 258 bp
>AT198844 NZ_CP097031:303622-303687 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQ28 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829C9W5 |