Detailed information of TA system TA198843

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 2863551..2864260
• Replicon: chromosome
• Accession: NZ_CP072790
• Organism: Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: J8397_RS13480
• Protein ID: WP_003912787.1
• Coordinates: 2863551..2863964 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: P95006
• Locus tag: J8397_RS13485
• Protein ID: WP_003413167.1
• Coordinates: 2864003..2864260 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8397_RS13450 (J8397_13275)	2858604..2859809	-	1206	WP_003413027.1	chorismate synthase	-
J8397_RS13455 (J8397_13280)	2859917..2860231	+	315	WP_009937839.1	hypothetical protein	-
J8397_RS13460 (J8397_13285)	2860527..2861738	+	1212	WP_003900845.1	alpha/beta hydrolase family protein	-
J8397_RS13465 (J8397_13290)	2861865..2862524	+	660	WP_003900846.1	LppA family lipoprotein	-
J8397_RS13470 (J8397_13295)	2862521..2863183	+	663	WP_003900848.1	LppA family lipoprotein	-
J8397_RS13475 (J8397_13300)	2863180..2863458	+	279	WP_003901422.1	type II toxin-antitoxin system VapB family antitoxin	-
J8397_RS13480 (J8397_13305)	2863551..2863964	+	414	WP_003912787.1	PIN domain nuclease	Toxin
J8397_RS13485 (J8397_13310)	2864003..2864260	+	258	WP_003413167.1	CopG family transcriptional regulator	Antitoxin
J8397_RS13490 (J8397_13315)	2864257..2864634	+	378	WP_003413174.1	type II toxin-antitoxin system VapC family toxin	-
J8397_RS13495 (J8397_13320)	2864650..2865024	-	375	WP_003413177.1	hypothetical protein	-
J8397_RS13500 (J8397_13325)	2865124..2865519	-	396	WP_003413180.1	type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20	-
J8397_RS13505 (J8397_13330)	2865516..2865761	-	246	WP_003413183.1	type II toxin-antitoxin system antitoxin VapB20	-
J8397_RS13510 (J8397_13335)	2866172..2866591	-	420	WP_003413190.1	A24 family peptidase	-
J8397_RS13515 (J8397_13340)	2866603..2867412	-	810	WP_003413193.1	shikimate dehydrogenase	-
J8397_RS13520 (J8397_13345)	2867409..2868662	-	1254	WP_003413196.1	endolytic transglycosylase MltG	-
J8397_RS13525 (J8397_13350)	2868655..2869167	-	513	WP_003413197.1	Holliday junction resolvase RuvX	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15044.06 Da
• Isoelectric Point: 6.1243

>T198843 WP_003912787.1 NZ_CP072790:2863551-2863964 [Mycobacterium tuberculosis]
MVFCVDTSAWHHAARPEVARRWLAALSADQIGICDHVRLEILYSANSATDYDALADELDGLARIPVGAKTFTRACQVQRE
LAHVAGLHHRSVKIADLVIAAAAELSGTIVWHYDENYDRVAAITGQPTEWIVPRGTL

Nucleotide

• Length: 414 bp

>T198843 NZ_CP097030:2681978-2682121 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9453.63 Da
• Isoelectric Point: 10.6555

>AT198843 WP_003413167.1 NZ_CP072790:2864003-2864260 [Mycobacterium tuberculosis]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Nucleotide

• Length: 258 bp

>AT198843 NZ_CP097030:c2682315-2682053 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATATCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Structures

Antitoxin

• AlphaFold DB: A0A829C9W5