Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2364583..2365278 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name vapC Uniprot ID O53501
Locus tag J8397_RS11095 Protein ID WP_003410811.1
Coordinates 2364583..2365017 (-) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TMN0
Locus tag J8397_RS11100 Protein ID WP_003410814.1
Coordinates 2365024..2365278 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS11085 (J8397_10940) 2360737..2363778 + 3042 WP_003899171.1 DEAD/DEAH box helicase -
J8397_RS11090 (J8397_10945) 2363771..2364604 + 834 WP_003899172.1 SWIM zinc finger family protein -
J8397_RS11095 (J8397_10950) 2364583..2365017 - 435 WP_003410811.1 type II toxin-antitoxin system VapC family toxin Toxin
J8397_RS11100 (J8397_10955) 2365024..2365278 - 255 WP_003410814.1 antitoxin Antitoxin
J8397_RS11105 (J8397_10960) 2365294..2365551 - 258 WP_003410816.1 hypothetical protein -
J8397_RS11110 (J8397_10965) 2365996..2367257 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
J8397_RS11115 (J8397_10970) 2367857..2368153 + 297 WP_003410820.1 PE family protein -
J8397_RS11120 (J8397_10975) 2368209..2368940 + 732 WP_003900467.1 PPE family protein -
J8397_RS11125 (J8397_10980) 2369480..2370226 - 747 WP_003906749.1 proteasome subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15662.08 Da        Isoelectric Point: 7.4681

>T198839 WP_003410811.1 NZ_CP072790:c2365017-2364583 [Mycobacterium tuberculosis]
MKIVDANVLLYAVNTTSEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Download         Length: 435 bp

>T198839 NZ_CP097030:2681291-2681488 [Enterococcus faecalis]
ATGTGTAGAGAAGTTATGGCGGTGGCTATCCAATCTGAAAGAGAGGTGATGCGTATGCACGTATTTCCGAAATTTAGAGA
AAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACAATTCTTGGGTTTGGTATGTTTACCATTGCTTTGATTGCGC
TGATTGTGAAATTGCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9417.57 Da        Isoelectric Point: 8.9912

>AT198839 WP_003410814.1 NZ_CP072790:c2365278-2365024 [Mycobacterium tuberculosis]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT198839 NZ_CP097030:c2681605-2681421 [Enterococcus faecalis]
TGCTACAATAGAGACGAAAAGAGAGGTATGCTCTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCTTTTTA
GTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCA
ATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FB09

Antitoxin

Source ID Structure
AlphaFold DB G0TMN0

References