Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 2220844..2221532 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name vapC Uniprot ID P0A653
Locus tag J8397_RS10440 Protein ID WP_003409958.1
Coordinates 2220844..2221263 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ28
Locus tag J8397_RS10445 Protein ID WP_003409968.1
Coordinates 2221272..2221532 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS10420 (J8397_10285) 2216339..2217187 + 849 WP_003409942.1 class I SAM-dependent methyltransferase -
J8397_RS10425 (J8397_10290) 2217150..2218595 - 1446 WP_003899115.1 APC family permease -
J8397_RS10430 (J8397_10295) 2218774..2219460 - 687 WP_003409954.1 immunoprotective protein Mpt64 -
J8397_RS10435 (J8397_10300) 2219651..2220619 - 969 WP_003899116.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
J8397_RS10440 (J8397_10305) 2220844..2221263 - 420 WP_003409958.1 type II toxin-antitoxin system VapC family toxin Toxin
J8397_RS10445 (J8397_10310) 2221272..2221532 - 261 WP_003409968.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J8397_RS10450 (J8397_10315) 2221675..2223351 + 1677 WP_003899118.1 PecA family PE domain-processing aspartic protease -
J8397_RS10455 (J8397_10320) 2223339..2223992 - 654 WP_003409976.1 cutinase Cfp21 -
J8397_RS10460 (J8397_10325) 2224107..2224337 + 231 WP_003409980.1 DUF167 domain-containing protein -
J8397_RS10465 (J8397_10330) 2224422..2225333 - 912 WP_003409986.1 ArgP/LysG family DNA-binding transcriptional regulator -
J8397_RS10470 (J8397_10335) 2225442..2226041 + 600 WP_003409989.1 L-lysine exporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-125)

Antitoxin

Antitoxin VapB-like

(2-81)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14724.89 Da        Isoelectric Point: 7.9535

>T198833 WP_003409958.1 NZ_CP072790:c2221263-2220844 [Mycobacterium tuberculosis]
MIVDTSAVVALVQGERPHATLVAAALAGAHSPVMSAPTVAECLIVLTARHGPVARTIFERLRSEIGLSVSSFTAEHAAAT
QRAFLRYGKGRHRAALNFGDCMTYATAQLGHQPLLAVGNDFPQTDLEFRGVVGYWPGVA

Download         Length: 420 bp

>T198833 NZ_CP097030:c320616-320521 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9528.88 Da        Isoelectric Point: 5.1007

>AT198833 WP_003409968.1 NZ_CP072790:c2221532-2221272 [Mycobacterium tuberculosis]
VALNIKDPEVDRLAAELADRLHTSKTAAIRHALSAQLAFLESRAGDREAQLLDILRTEIWPLLADRSPITKLEREQILGY
DPATGV

Download         Length: 261 bp

>AT198833 NZ_CP097030:320422-320486 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829C4H9

Antitoxin

Source ID Structure
AlphaFold DB A0A829C483

References