Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1394818..1395377 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name relE Uniprot ID G0THS1
Locus tag J8397_RS06675 Protein ID WP_003898789.1
Coordinates 1394818..1395111 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0THS2
Locus tag J8397_RS06680 Protein ID WP_003406322.1
Coordinates 1395108..1395377 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS06650 (J8397_06520) 1390411..1390671 + 261 WP_003406302.1 type II toxin-antitoxin system antitoxin VapB33 -
J8397_RS06655 (J8397_06525) 1390668..1391099 + 432 WP_003406304.1 type II toxin-antitoxin system VapC family toxin -
J8397_RS06660 (J8397_06530) 1391122..1392810 - 1689 WP_003910308.1 PE family protein -
J8397_RS06665 (J8397_06535) 1392990..1393850 + 861 WP_003900301.1 glycine betaine ABC transporter substrate-binding protein -
J8397_RS06670 (J8397_06540) 1393931..1394761 - 831 WP_003898788.1 SDR family NAD(P)-dependent oxidoreductase -
J8397_RS06675 (J8397_06545) 1394818..1395111 - 294 WP_003898789.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
J8397_RS06680 (J8397_06550) 1395108..1395377 - 270 WP_003406322.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
J8397_RS06685 (J8397_06555) 1395490..1399185 - 3696 WP_003898790.1 multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit -
J8397_RS06690 (J8397_06560) 1399327..1400115 - 789 WP_003406325.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11031.57 Da        Isoelectric Point: 9.6275

>T198823 WP_003898789.1 NZ_CP072790:c1395111-1394818 [Mycobacterium tuberculosis]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Download         Length: 294 bp

>T198823 NZ_CP097020:2662712-2662855 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAACCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9766.97 Da        Isoelectric Point: 4.8615

>AT198823 WP_003406322.1 NZ_CP072790:c1395377-1395108 [Mycobacterium tuberculosis]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Download         Length: 270 bp

>AT198823 NZ_CP097020:c2662601-2662455 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCTTT
TTGATTATTTAAAAATAACCGTACTGGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0THS1

Antitoxin

Source ID Structure
AlphaFold DB G0THS2

References