Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1029303..1030276 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name tacT Uniprot ID O05911
Locus tag J8397_RS04900 Protein ID WP_003404756.1
Coordinates 1029776..1030276 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID O05910
Locus tag J8397_RS04895 Protein ID WP_003898647.1
Coordinates 1029303..1029779 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS04875 (J8397_04825) 1025150..1026421 - 1272 WP_003404747.1 PPE family protein -
J8397_RS04880 (J8397_04830) 1026436..1026735 - 300 WP_003404748.1 PE family protein -
J8397_RS04885 (J8397_04835) 1027179..1028960 + 1782 WP_003404749.1 BCCT family transporter -
J8397_RS04890 (J8397_04840) 1028960..1029214 + 255 WP_003898646.1 hypothetical protein -
J8397_RS04895 (J8397_04845) 1029303..1029779 + 477 WP_003898647.1 DUF1778 domain-containing protein Antitoxin
J8397_RS04900 (J8397_04850) 1029776..1030276 + 501 WP_003404756.1 GNAT family N-acetyltransferase Toxin
J8397_RS04910 (J8397_04860) 1030589..1031908 - 1320 WP_003404757.1 IS256-like element IS1554 family transposase -
J8397_RS04915 (J8397_04865) 1032196..1032777 + 582 WP_003404760.1 IS607-like element IS1535 family transposase -
J8397_RS04920 (J8397_04870) 1032777..1034429 + 1653 WP_003404761.1 IS607 family element RNA-guided endonuclease TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(38-143)

Antitoxin

Vibrio phage ICP1, Orf50

(74-150)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 18048.55 Da        Isoelectric Point: 7.8659

>T198818 WP_003404756.1 NZ_CP072790:1029776-1030276 [Mycobacterium tuberculosis]
VSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPD
PVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDA
RALIGD

Download         Length: 501 bp

>T198818 NZ_CP097020:c2571261-2571118 [Enterococcus faecalis]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTGTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 17387.98 Da        Isoelectric Point: 11.2467

>AT198818 WP_003898647.1 NZ_CP072790:1029303-1029779 [Mycobacterium tuberculosis]
MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGSSGLPALNCTPIRHTIDVMATKPERKTERLAARLT
PEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG

Download         Length: 477 bp

>AT198818 NZ_CP097020:2570999-2571185 [Enterococcus faecalis]
TGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGATT
TTGTTACAAAAAATAACCGTACTCGATCAAAGTAAACGGTTATTTTTTATTGTCATTTTTAAGCAATTTCACAATCAGCG
CAATCAAAGCAATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSZ2

Antitoxin

Source ID Structure
AlphaFold DB A5U0V8

References