Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1019773..1020392 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag J8397_RS04845 Protein ID WP_003404726.1
Coordinates 1019958..1020392 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ06
Locus tag J8397_RS04840 Protein ID WP_003898641.1
Coordinates 1019773..1019952 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS04825 (J8397_04775) 1015246..1016826 + 1581 WP_003909313.1 serine hydrolase -
J8397_RS04830 (J8397_04780) 1016823..1019216 + 2394 WP_003898639.1 cation-translocating P-type ATPase -
J8397_RS04835 (J8397_04785) 1019489..1019647 + 159 WP_003404720.1 hypothetical protein -
J8397_RS04840 (J8397_04790) 1019773..1019952 + 180 WP_003898641.1 antitoxin Antitoxin
J8397_RS04845 (J8397_04795) 1019958..1020392 + 435 WP_003404726.1 SRPBCC family protein Toxin
J8397_RS04850 (J8397_04800) 1020490..1021263 + 774 WP_003404735.1 VOC family protein -
J8397_RS04855 (J8397_04805) 1021328..1021777 + 450 WP_003404738.1 hypothetical protein -
J8397_RS04860 (J8397_04810) 1021912..1022142 - 231 WP_003898642.1 hypothetical protein -
J8397_RS04865 (J8397_04815) 1022309..1023817 - 1509 WP_003404742.1 carotenoid oxygenase family protein -
J8397_RS04870 (J8397_04820) 1023819..1025057 - 1239 WP_003404744.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15754.47 Da        Isoelectric Point: 9.7977

>T198817 WP_003404726.1 NZ_CP072790:1019958-1020392 [Mycobacterium tuberculosis]
MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLN
GDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG

Download         Length: 435 bp

>T198817 NZ_CP097020:c2496756-2496655 [Enterococcus faecalis]
TTGTCAATCGAAGCGACATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6403.07 Da        Isoelectric Point: 4.5393

>AT198817 WP_003898641.1 NZ_CP072790:1019773-1019952 [Mycobacterium tuberculosis]
MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLHDAASNVVGMSDQQS

Download         Length: 180 bp

>AT198817 NZ_CP097020:2496530-2496710 [Enterococcus faecalis]
TGAAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAG
TTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATAC
CGAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A045KDK5

References