Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 846039..846748 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name vapC Uniprot ID P9WF74
Locus tag J8397_RS04000 Protein ID WP_003403837.1
Coordinates 846320..846748 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TEX4
Locus tag J8397_RS03995 Protein ID WP_003403834.1
Coordinates 846039..846296 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS03990 (J8397_03940) 843543..845948 + 2406 WP_012054160.1 PE family protein -
J8397_RS03995 (J8397_03945) 846039..846296 + 258 WP_003403834.1 ribbon-helix-helix protein, CopG family Antitoxin
J8397_RS04000 (J8397_03950) 846320..846748 + 429 WP_003403837.1 type II toxin-antitoxin system VapC family toxin Toxin
J8397_RS04005 (J8397_03955) 846829..846966 - 138 WP_003403839.1 hypothetical protein -
J8397_RS04015 (J8397_03960) 847125..847370 + 246 WP_003403841.1 hypothetical protein -
J8397_RS04020 (J8397_03965) 847439..848323 - 885 WP_003403844.1 3-hydroxyisobutyrate dehydrogenase -
J8397_RS04025 (J8397_03970) 848334..849506 - 1173 WP_003403845.1 acyl-CoA dehydrogenase family protein -
J8397_RS04030 (J8397_03975) 849513..851045 - 1533 WP_003403847.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15831.27 Da        Isoelectric Point: 7.5536

>T198816 WP_003403837.1 NZ_CP072790:846320-846748 [Mycobacterium tuberculosis]
MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHL
PTNPGPRHLMLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL

Download         Length: 429 bp

>T198816 NZ_CP097020:c2496321-2496220 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACAATAAAAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9114.28 Da        Isoelectric Point: 10.6530

>AT198816 WP_003403834.1 NZ_CP072790:846039-846296 [Mycobacterium tuberculosis]
MRTTVSISDEILAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGIDLTSNRALSEVLDEGLE
LNSRK

Download         Length: 258 bp

>AT198816 NZ_CP097020:2496101-2496275 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTT
TTGAATCTTAACCGTTCGGCCTACGAAGCTTGTGAACGGTTATTTTTTATTGTTTTTCGTTGCTTCAAGGATACCGAAAA
TCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CDR3

Antitoxin

Source ID Structure
AlphaFold DB G0TEX4

References