Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapC-mazE/PIN(toxin) |
Location | 760018..760810 | Replicon | chromosome |
Accession | NZ_CP072790 | ||
Organism | Mycobacterium tuberculosis strain I0003447-5 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | P9WFB2 |
Locus tag | J8397_RS03520 | Protein ID | WP_003403386.1 |
Coordinates | 760373..760810 (-) | Length | 146 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | G0TQE0 |
Locus tag | J8397_RS03515 | Protein ID | WP_003403381.1 |
Coordinates | 760018..760263 (-) | Length | 82 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
J8397_RS03485 (J8397_03445) | 755038..756543 | + | 1506 | WP_003403360.1 | carotenoid cleavage oxygenase | - |
J8397_RS03490 (J8397_03450) | 756624..757634 | + | 1011 | WP_003911248.1 | ABC transporter ATP-binding protein | - |
J8397_RS03495 (J8397_03455) | 758022..758405 | - | 384 | WP_003912919.1 | ribonuclease VapC6 | - |
J8397_RS03500 (J8397_03460) | 758500..758655 | - | 156 | WP_003403368.1 | type II toxin-antitoxin system VapB family antitoxin | - |
J8397_RS03505 (J8397_03465) | 758731..759447 | - | 717 | WP_003403371.1 | CPBP family intramembrane metalloprotease | - |
J8397_RS03510 (J8397_03470) | 759723..760031 | - | 309 | WP_003403376.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
J8397_RS03515 (J8397_03475) | 760018..760263 | - | 246 | WP_003403381.1 | ribbon-helix-helix protein, CopG family | Antitoxin |
J8397_RS03520 (J8397_03480) | 760373..760810 | - | 438 | WP_003403386.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
J8397_RS03525 (J8397_03485) | 760807..761061 | - | 255 | WP_003911263.1 | antitoxin VapB7 | - |
J8397_RS03530 (J8397_03490) | 761175..763538 | + | 2364 | WP_003898547.1 | arylsulfatase AtsD | - |
J8397_RS03535 (J8397_03495) | 763601..763927 | + | 327 | WP_003403401.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
J8397_RS03540 (J8397_03500) | 763839..764177 | + | 339 | WP_003403405.1 | PIN domain-containing protein | - |
J8397_RS03545 (J8397_03505) | 764174..764347 | + | 174 | WP_003898549.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 146 a.a. Molecular weight: 15245.39 Da Isoelectric Point: 5.1865
>T198814 WP_003403386.1 NZ_CP072790:c760810-760373 [Mycobacterium tuberculosis]
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR
MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIE
ATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR
Download Length: 438 bp
>T198814 NZ_CP097020:c308528-308433 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9169.01 Da Isoelectric Point: 4.2070
>AT198814 WP_003403381.1 NZ_CP072790:c760263-760018 [Mycobacterium tuberculosis]
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R
MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAA
R
Download Length: 246 bp
>AT198814 NZ_CP097020:308334-308398 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U4BSW5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G0TQE0 |