Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 715287..715912 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name vapC Uniprot ID G0TQA0
Locus tag J8397_RS03275 Protein ID WP_003403218.1
Coordinates 715511..715912 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ36
Locus tag J8397_RS03270 Protein ID WP_003403213.1
Coordinates 715287..715514 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS03245 (J8397_03205) 710466..710687 - 222 WP_003898525.1 DUF4926 domain-containing protein -
J8397_RS03250 (J8397_03210) 710829..711434 + 606 WP_003898526.1 hypothetical protein -
J8397_RS03255 (J8397_03215) 711453..714020 - 2568 WP_003900188.1 SEC-C metal-binding domain-containing protein -
J8397_RS03260 (J8397_03220) 714104..714853 + 750 WP_003898528.1 hypothetical protein -
J8397_RS03265 (J8397_03225) 714850..715092 + 243 WP_003403210.1 hypothetical protein -
J8397_RS03270 (J8397_03230) 715287..715514 + 228 WP_003403213.1 antitoxin VapB29 Antitoxin
J8397_RS03275 (J8397_03235) 715511..715912 + 402 WP_003403218.1 type II toxin-antitoxin system ribonuclease VapC29 Toxin
J8397_RS03280 716041..716124 + 84 Protein_649 galactose-1-phosphate uridylyltransferase -
J8397_RS03285 716143..717224 + 1082 Protein_650 galactose-1-phosphate uridylyltransferase -
J8397_RS03290 (J8397_03250) 717221..718312 + 1092 WP_003906403.1 galactokinase -
J8397_RS03295 (J8397_03255) 718707..719771 + 1065 WP_003898532.1 zinc ribbon domain-containing protein -
J8397_RS03300 (J8397_03260) 719875..720822 + 948 WP_003403232.1 DUF732 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13937.76 Da        Isoelectric Point: 5.7441

>T198809 WP_003403218.1 NZ_CP072790:715511-715912 [Mycobacterium tuberculosis]
VTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALS
FAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT

Download         Length: 402 bp

>T198809 NZ_CP097011:c69957-69616 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGCTGAAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACATTGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCAACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGACTTTGCAGAAAGAAAGTTAAGCCAAATAGAACATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8163.17 Da        Isoelectric Point: 5.6307

>AT198809 WP_003403213.1 NZ_CP072790:715287-715514 [Mycobacterium tuberculosis]
VRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT198809 NZ_CP097011:c70187-69957 [Enterococcus faecalis]
ATGTTAACCACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTGATGTATTCTGATGATGGGACAATTACGTTAGTCCCTAAATTACAAGACCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQA0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BSC9

References