Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 707749..708392 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name vapC Uniprot ID P67239
Locus tag J8397_RS03225 Protein ID WP_003403187.1
Coordinates 707991..708392 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ91
Locus tag J8397_RS03220 Protein ID WP_003403184.1
Coordinates 707749..707994 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS03185 (J8397_03145) 703149..703559 - 411 WP_070892737.1 HAMP domain-containing protein -
J8397_RS03190 (J8397_03150) 703543..704238 - 696 WP_206647908.1 response regulator transcription factor -
J8397_RS03195 (J8397_03155) 704361..704672 + 312 WP_003403164.1 hypothetical protein -
J8397_RS03200 (J8397_03160) 704744..705694 + 951 WP_003900184.1 DUF1259 domain-containing protein -
J8397_RS03205 (J8397_03165) 705935..706519 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
J8397_RS03210 (J8397_03170) 706521..707231 + 711 Protein_635 IS607 family element RNA-guided endonuclease TnpB -
J8397_RS03215 (J8397_03175) 707234..707704 + 471 WP_003898523.1 hypothetical protein -
J8397_RS03220 (J8397_03180) 707749..707994 + 246 WP_003403184.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J8397_RS03225 (J8397_03185) 707991..708392 + 402 WP_003403187.1 type II toxin-antitoxin system VapC family toxin Toxin
J8397_RS03230 708383..708562 + 180 Protein_639 hypothetical protein -
J8397_RS03235 (J8397_03195) 708980..709177 - 198 WP_003403191.1 hypothetical protein -
J8397_RS03240 (J8397_03200) 709257..710414 - 1158 WP_003898524.1 hypothetical protein -
J8397_RS03245 (J8397_03205) 710466..710687 - 222 WP_003898525.1 DUF4926 domain-containing protein -
J8397_RS03250 (J8397_03210) 710829..711434 + 606 WP_003898526.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14501.21 Da        Isoelectric Point: 4.4463

>T198808 WP_003403187.1 NZ_CP072790:707991-708392 [Mycobacterium tuberculosis]
VIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLAR
AAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR

Download         Length: 402 bp

>T198808 NZ_CP097010:1512830-1512940 [Enterococcus faecalis]
TTGTCCGTTGAAGCAGCGCTAGGACTGATGATTGGTTTTGCAACACTTGTTGTGACCATTATCTTCGGTATCTTAGCGCT
TGTCTTAGACAACAAAAATAACCGTTCATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8813.12 Da        Isoelectric Point: 10.3486

>AT198808 WP_003403184.1 NZ_CP072790:707749-707994 [Mycobacterium tuberculosis]
MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLP
A

Download         Length: 246 bp

>AT198808 NZ_CP097010:c1513056-1512851 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAGTAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BSD6

Antitoxin

Source ID Structure
AlphaFold DB G0TQ91

References