Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/AbrB(antitoxin)
Location 701779..702425 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ88
Locus tag J8397_RS03170 Protein ID WP_003403137.1
Coordinates 701779..702192 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TQ89
Locus tag J8397_RS03175 Protein ID WP_003403139.1
Coordinates 702189..702425 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS03150 (J8397_03110) 697862..699412 + 1551 WP_003403119.1 MlaD family protein -
J8397_RS03155 (J8397_03115) 699464..699856 - 393 WP_003403122.1 type II toxin-antitoxin system toxin ribonuclease C4 -
J8397_RS03160 (J8397_03120) 699853..700110 - 258 WP_003403125.1 type II toxin-antitoxin system antitoxin VapB4 -
J8397_RS03165 (J8397_03125) 700293..701528 - 1236 WP_003403128.1 ATP-binding protein -
J8397_RS03170 (J8397_03130) 701779..702192 - 414 WP_003403137.1 type II toxin-antitoxin system VapC family toxin Toxin
J8397_RS03175 (J8397_03135) 702189..702425 - 237 WP_003403139.1 type II toxin-antitoxin system antitoxin VapB27 Antitoxin
J8397_RS03180 (J8397_03140) 702529..703035 - 507 WP_003900973.1 two component system sensor kinase HK1 -
J8397_RS03185 (J8397_03145) 703149..703559 - 411 WP_070892737.1 HAMP domain-containing protein -
J8397_RS03190 (J8397_03150) 703543..704238 - 696 WP_206647908.1 response regulator transcription factor -
J8397_RS03195 (J8397_03155) 704361..704672 + 312 WP_003403164.1 hypothetical protein -
J8397_RS03200 (J8397_03160) 704744..705694 + 951 WP_003900184.1 DUF1259 domain-containing protein -
J8397_RS03205 (J8397_03165) 705935..706519 + 585 WP_003403171.1 IS607-like element IS1536 family transposase -
J8397_RS03210 (J8397_03170) 706521..707231 + 711 Protein_635 IS607 family element RNA-guided endonuclease TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-126)

Antitoxin

SpoVT-AbrB domain

(3-43)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14786.14 Da        Isoelectric Point: 8.1405

>T198807 WP_003403137.1 NZ_CP072790:c702192-701779 [Mycobacterium tuberculosis]
VKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSR
TTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA

Download         Length: 414 bp

>T198807 NZ_CP097010:c1331244-1331149 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCTATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8212.41 Da        Isoelectric Point: 5.0351

>AT198807 WP_003403139.1 NZ_CP072790:c702425-702189 [Mycobacterium tuberculosis]
MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK

Download         Length: 237 bp

>AT198807 NZ_CP097010:1331049-1331114 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATCAGTAGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ88

Antitoxin

Source ID Structure
AlphaFold DB G0TQ89

References