Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 682335..682954 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name vapC Uniprot ID O53779
Locus tag J8397_RS03090 Protein ID WP_003403047.1
Coordinates 682547..682954 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID O53778
Locus tag J8397_RS03085 Protein ID WP_003403039.1
Coordinates 682335..682550 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS03075 (J8397_03035) 680863..681621 + 759 WP_003898511.1 Mut7-C RNAse domain-containing protein -
J8397_RS03080 (J8397_03040) 681750..682241 - 492 WP_003403017.1 mycobacterial cell wall protein Rv0580c -
J8397_RS03085 (J8397_03045) 682335..682550 + 216 WP_003403039.1 type II toxin-antitoxin system antitoxin VapB26 Antitoxin
J8397_RS03090 (J8397_03050) 682547..682954 + 408 WP_003403047.1 type II toxin-antitoxin system toxin ribonuclease C26 Toxin
J8397_RS03095 (J8397_03055) 683014..683700 - 687 WP_003403052.1 LpqN/LpqT family lipoprotein -
J8397_RS03100 (J8397_03060) 683854..686487 + 2634 WP_003403055.1 GH92 family glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-39)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14471.43 Da        Isoelectric Point: 4.4493

>T198805 WP_003403047.1 NZ_CP072790:682547-682954 [Mycobacterium tuberculosis]
VIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQ
AARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP

Download         Length: 408 bp

>T198805 NZ_CP097010:912258-912401 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7572.66 Da        Isoelectric Point: 10.5454

>AT198805 WP_003403039.1 NZ_CP072790:682335-682550 [Mycobacterium tuberculosis]
VDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER

Download         Length: 216 bp

>AT198805 NZ_CP097010:c912147-912014 [Enterococcus faecalis]
TTGTGCTATAATAGCAATGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACCCGT
TATTATTTAAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5X3T

Antitoxin

Source ID Structure
PDB 5X3T
AlphaFold DB A0A7U4BSA2

References