Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-CcdA
Location 644853..645529 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name vapC Uniprot ID G0TPQ9
Locus tag J8397_RS02920 Protein ID WP_003898500.1
Coordinates 644853..645266 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TPR0
Locus tag J8397_RS02925 Protein ID WP_003402915.1
Coordinates 645263..645529 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS02890 (J8397_02850) 640198..640500 - 303 WP_003402896.1 DUF3349 domain-containing protein -
J8397_RS02895 (J8397_02855) 640560..640838 - 279 WP_003402901.1 hypothetical protein -
J8397_RS02900 (J8397_02860) 640835..642088 - 1254 WP_003402904.1 inorganic phosphate transporter -
J8397_RS02905 (J8397_02865) 642208..642594 - 387 WP_003402907.1 VOC family protein -
J8397_RS02910 (J8397_02870) 642657..643541 - 885 WP_003402909.1 SDR family oxidoreductase -
J8397_RS02915 (J8397_02875) 643637..644539 - 903 WP_003915439.1 1,4-dihydroxy-2-naphthoyl-CoA synthase -
J8397_RS02920 (J8397_02880) 644853..645266 - 414 WP_003898500.1 type II toxin-antitoxin system VapC family toxin Toxin
J8397_RS02925 (J8397_02885) 645263..645529 - 267 WP_003402915.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
J8397_RS02930 (J8397_02890) 645721..647436 - 1716 WP_003402917.1 fatty-acid--CoA ligase FadD8 -
J8397_RS02935 (J8397_02895) 647514..649118 + 1605 WP_003402920.1 amidohydrolase -
J8397_RS02940 (J8397_02900) 649115..650095 + 981 WP_003402923.1 o-succinylbenzoate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(13-129)

Antitoxin

Post-segregation antitoxin CcdA

(19-61)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14667.78 Da        Isoelectric Point: 7.3603

>T198804 WP_003898500.1 NZ_CP072790:c645266-644853 [Mycobacterium tuberculosis]
VRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQV
PVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG

Download         Length: 414 bp

>T198804 NZ_CP097010:907590-907694 [Enterococcus faecalis]
TTGTCAGCATATGAGACAATTCAGACGATTCTAGGTTTTGGTATGTTTACCATTGCTTTGATTGCGCTGATTGTGAAATT
GCTTAAAAATGACAAGAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9543.79 Da        Isoelectric Point: 4.5994

>AT198804 WP_003402915.1 NZ_CP072790:c645529-645263 [Mycobacterium tuberculosis]
MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAID
AARDEFEA

Download         Length: 267 bp

>AT198804 NZ_CP097010:c907882-907627 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTGAAATAGGAGGCTCAGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAATGA
TAAAGAAAAGAGAGATATGCTTCCAACATATCTCTCTGATGTAGAGCCGTTTAAGACGGTGACCGTGTTAATTATTTAAA
AATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGCGCAATCAAAGCA
ATGGTAAACATACCAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TPQ9

Antitoxin

Source ID Structure
AlphaFold DB G0TPR0

References