Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 448726..449737 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag J8397_RS01960 Protein ID WP_003401859.1
Coordinates 448726..449319 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag J8397_RS01965 Protein ID WP_003401860.1
Coordinates 449348..449737 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS01940 (J8397_01905) 444375..445757 + 1383 WP_003898415.1 magnesium transporter -
J8397_RS01945 (J8397_01910) 445769..446803 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
J8397_RS01950 (J8397_01915) 446899..447582 + 684 WP_003401857.1 VTT domain-containing protein -
J8397_RS01955 (J8397_01920) 447571..448701 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
J8397_RS01960 (J8397_01925) 448726..449319 - 594 WP_003401859.1 zeta toxin family protein Toxin
J8397_RS01965 (J8397_01930) 449348..449737 - 390 WP_003401860.1 hypothetical protein Antitoxin
J8397_RS01970 (J8397_01935) 449818..451029 - 1212 WP_003906353.1 VWA domain-containing protein -
J8397_RS01975 (J8397_01940) 451035..451637 - 603 WP_003898417.1 SRPBCC family protein -
J8397_RS01980 (J8397_01945) 451651..452547 - 897 WP_003898418.1 MoxR family ATPase -
J8397_RS01985 (J8397_01950) 452544..453137 - 594 WP_003401864.1 NTP transferase domain-containing protein -
J8397_RS01990 (J8397_01955) 453134..453889 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T198803 WP_003401859.1 NZ_CP072790:c449319-448726 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T198803 NZ_CP097010:c902194-901853 [Enterococcus faecalis]
ATGAACGTTGAAAAGAAGTACATTCCCAAAAAAGGAGATATTGTATGGATTGATTTTGATCCTGCTGCAGGTAAAGAAAT
TCAGAAGAGACGCCCTGGTTTAGTCGTGTCAAGATATGAATTTAATCGGAAAACCATGTTTGCTGTGATTTGCCCGATTA
CTTCCACCATTAAAAATATTCCCACTCGATATACGTTGCCCGATGACATAGAAACCCATGGGCAAGTAGTGATCTCACAA
CTGAAATCTTTGGACTTCACTGAAAGAAAATTAAGTCAAATTGAGCATTTGCCATTAAAAGATATGGCGAAAATTGACCA
AATAATTGAATATATTTTCTAG

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT198803 WP_003401860.1 NZ_CP072790:c449737-449348 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT198803 NZ_CP097010:c902424-902194 [Enterococcus faecalis]
ATGCTAACAACTAAATCAAGAAGACAAGGAAACTCGGTCGTTTTAACTTTACCCACTGATAATGGTAAAAAACCAAAAGT
CGACCAAGAATATATTGTGATGTATTCTGACGATGGTACAATTACATTAGTCCCTAAAATTCAGGATCCATTTAGTGAAG
GTCCAGAAGGTGAGTATTATGAAAAAGATGAGTGGCATGATCTTGCACCTGAGGGGAGAGAACTTTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References