Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 367720..368246 Replicon chromosome
Accession NZ_CP072790
Organism Mycobacterium tuberculosis strain I0003447-5

Toxin (Protein)


Gene name Rv0299 Uniprot ID -
Locus tag J8397_RS01595 Protein ID WP_003401560.1
Coordinates 367944..368246 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID P9WJ08
Locus tag J8397_RS01590 Protein ID WP_003401555.1
Coordinates 367720..367947 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8397_RS01575 (J8397_01575) 363413..364216 - 804 WP_003401540.1 Stf0 family sulphotransferase -
J8397_RS01580 (J8397_01580) 364226..365623 - 1398 WP_003401544.1 sulfatase -
J8397_RS01585 (J8397_01585) 365802..367577 + 1776 WP_010886074.1 PE family protein -
J8397_RS01590 (J8397_01590) 367720..367947 + 228 WP_003401555.1 ribbon-helix-helix protein, CopG family Antitoxin
J8397_RS01595 (J8397_01595) 367944..368246 + 303 WP_003401560.1 toxin-antitoxin system toxin Toxin
J8397_RS01600 (J8397_01600) 368294..368515 + 222 WP_003401563.1 type II toxin-antitoxin system antitoxin VapB2 -
J8397_RS01605 (J8397_01605) 368512..368937 + 426 WP_003401566.1 PIN domain nuclease -
J8397_RS01610 (J8397_01610) 369073..369705 + 633 WP_003401571.1 TetR/AcrR family transcriptional regulator -
J8397_RS01615 (J8397_01615) 369702..370610 + 909 WP_003900117.1 protochlorophyllide reductase -
J8397_RS01620 370618..371949 - 1332 WP_234774183.1 hypothetical protein -
J8397_RS01625 372482..372544 - 63 Protein_321 hypothetical protein -
J8397_RS01630 372643..372729 - 87 Protein_322 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 10442.16 Da        Isoelectric Point: 4.9609

>T198800 WP_003401560.1 NZ_CP072790:367944-368246 [Mycobacterium tuberculosis]
MIAPGDIAPRRDSEHELYVAVLSNALHRAADTGRVITCPFIPGRVPEDLLAMVVAVEQPNGTLLPELVQWLHVAALGAPL
GNAGVAALREAASVVTALLC

Download         Length: 303 bp

>T198800 NZ_CP097010:c760502-760401 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8130.21 Da        Isoelectric Point: 7.0084

>AT198800 WP_003401555.1 NZ_CP072790:367720-367947 [Mycobacterium tuberculosis]
MTKEKISVTVDAAVLAAIDADARAAGLNRSEMIEQALRNEHLRVALRDYTAKTVPALDIDAYAQRVYQANRAAGS

Download         Length: 228 bp

>AT198800 NZ_CP097010:760279-760456 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4F8T1

References