Detailed information of TA system TA198798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2699178..2699806
• Replicon: chromosome
• Accession: NZ_CP072789
• Organism: Geobacter sulfurreducens strain PL

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: Q74AB8
• Locus tag: J8622_RS12440
• Protein ID: WP_010943110.1
• Coordinates: 2699178..2699579 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q74AB7
• Locus tag: J8622_RS12445
• Protein ID: WP_010943111.1
• Coordinates: 2699579..2699806 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8622_RS12415 (J8622_12405)	2694274..2695299	+	1026	WP_010940724.1	IS21-like element ISGsu6 family transposase	-
J8622_RS12420 (J8622_12410)	2695296..2696090	+	795	WP_010940725.1	IS21-like element ISGsu6 family helper ATPase IstB	-
J8622_RS12425 (J8622_12415)	2696396..2696608	+	213	WP_254278065.1	hypothetical protein	-
J8622_RS12430 (J8622_12420)	2696985..2698172	+	1188	WP_082208812.1	DNA methyltransferase	-
J8622_RS12435 (J8622_12425)	2698187..2699095	+	909	WP_045667399.1	Bpu10I family restriction endonuclease	-
J8622_RS12440 (J8622_12430)	2699178..2699579	-	402	WP_010943110.1	type II toxin-antitoxin system VapC family toxin	Toxin
J8622_RS12445 (J8622_12435)	2699579..2699806	-	228	WP_010943111.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
J8622_RS12450 (J8622_12440)	2700390..2703200	+	2811	WP_014551840.1	GPMC system transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (7-53)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14702.12 Da
• Isoelectric Point: 4.8615

>T198798 WP_010943110.1 NZ_CP072789:c2699579-2699178 [Geobacter sulfurreducens]
MKLLLDTNICIYIIKQQPVAVLERFLEYQVGDIGISSITLSELRYGVAKSTHMEKNAKALDEFIIPLELVSYDESAAHVY
GDIRAALEKAGTPIGSMDMLIAAHAVSLGIPLVTNNTREFLRVPSLNIIDWTV

Nucleotide

• Length: 402 bp

>T198798 NZ_CP097009:c41604-41263 [Enterococcus faecalis]
ATGAGTGACGAAAAGAAATATATTCCTAAAAAGGGCGATATTGTATGGATAGATTTCGATCCTTCAGCTGAAAAAGAAAT
ACAGAAAAGACGTCCAGGTCTAGTAGTTTCTAGATATGAGTTTAATAGAAAGACATTGTTTGCAGTAATTTGTCCCATAA
CTTCTACAATTAAAAATATGCCAACTCGTTATACATTACCTGATGAAATGGAAACTCATGGACAAGTCGTTATTTCCCAA
TTAAAATCTTTAGACTTTGCAGAAAGAAAGTTAAGCCAAATAGAACATTTACCATTAAAGGATATGGCTAAAATAGATCA
AATCATTGAATACATTTTTTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8772.02 Da
• Isoelectric Point: 10.5623

>AT198798 WP_010943111.1 NZ_CP072789:c2699806-2699579 [Geobacter sulfurreducens]
MKTAKIFQNGQSQAVRLPKEFRFEDSEVFIKKSGNVVQLIPRSDSWNSLFGSLKKFSRDFMSERIQPELDKRDGF

Nucleotide

• Length: 228 bp

>AT198798 NZ_CP097009:c41834-41604 [Enterococcus faecalis]
ATGTTAACCACAAAATCTAGAAAACAAGGAAGTTCTGTAGTATTGACATTACCATCTAATAACGGACAGAAACCAAAAGC
AGACCAAGAATATATAGTGATGTATTCTGATGATGGGACAATTACGTTAGTCCCTAAATTACAAGACCCATTTAGTGGTG
GATCAGAAGGGGAGTACTACGAAAAAGATGAATGGCATGACATTGAACCTGGAGGGAGAGAATTATTTTAA

Structures

Toxin

• AlphaFold DB: Q74AB8

Antitoxin

• AlphaFold DB: Q74AB7