Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1678124..1678717 Replicon chromosome
Accession NZ_CP072789
Organism Geobacter sulfurreducens strain PL

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag J8622_RS07720 Protein ID WP_254278533.1
Coordinates 1678427..1678717 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag J8622_RS07715 Protein ID WP_254278573.1
Coordinates 1678124..1678357 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8622_RS07685 (J8622_07665) 1673214..1673402 - 189 WP_254278528.1 hypothetical protein -
J8622_RS07690 (J8622_07670) 1673549..1674781 + 1233 WP_254278529.1 SEC-C metal-binding domain-containing protein -
J8622_RS07695 (J8622_07675) 1674901..1675386 + 486 WP_254278530.1 hypothetical protein -
J8622_RS07700 (J8622_07680) 1675451..1675708 + 258 WP_254278531.1 alpha/beta hydrolase -
J8622_RS07705 (J8622_07685) 1675797..1676591 + 795 WP_254278532.1 transposase -
J8622_RS07710 (J8622_07690) 1676632..1678002 + 1371 WP_119332507.1 kelch repeat-containing protein -
J8622_RS07715 (J8622_07695) 1678124..1678357 - 234 WP_254278573.1 putative addiction module antidote protein Antitoxin
J8622_RS07720 (J8622_07700) 1678427..1678717 - 291 WP_254278533.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8622_RS07725 (J8622_07705) 1678831..1679277 + 447 WP_254278534.1 DUF2845 domain-containing protein -
J8622_RS07730 (J8622_07710) 1679372..1679986 + 615 WP_010942192.1 LysE family translocator -
J8622_RS07735 (J8622_07715) 1680186..1681031 + 846 WP_254278535.1 hypothetical protein -
J8622_RS07740 (J8622_07720) 1681111..1682532 + 1422 WP_010942194.1 tetratricopeptide repeat protein -
J8622_RS07745 (J8622_07725) 1682633..1683118 + 486 WP_010942195.1 ferritin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-94)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10732.46 Da        Isoelectric Point: 10.3861

>T198797 WP_254278533.1 NZ_CP072789:c1678717-1678427 [Geobacter sulfurreducens]
MIEIRKTELFAKWLDNLRDVKAKARVLVRIERLASGNPGDVKPVGDGISEMRIDYGPGYRVYFFQRGSELIVLLAGGDKG
SQSRDIKAAIRLAQNL

Download         Length: 291 bp

>T198797 NZ_CP097008:2622030-2622173 [Enterococcus faecalis]
ATGAATGTAAGTACTAAAATCTATGAAAGGAGAGGCCTTTTGTCTATCGCAGAAGCTTTAGCTCTGATGATTAGTTTCGG
TTCTTTTATCGCAACGTTAATCTTCGGAATCCTAGAGGCTGTTAAAGAAGACAATAAAAAATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8106.35 Da        Isoelectric Point: 7.0097

>AT198797 WP_254278573.1 NZ_CP072789:c1678357-1678124 [Geobacter sulfurreducens]
MAAYLEASLEEANGDATFIAKALGDIARAKGMSQVARDAGLSRESLYKALSGERVPSFDTILKIIAALGLKLHAEAK

Download         Length: 234 bp

>AT198797 NZ_CP097008:c2622367-2622105 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGACAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References