Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4173027..4173859 Replicon chromosome
Accession NZ_CP072787
Organism Escherichia coli strain NC101

Toxin (Protein)


Gene name yeeV Uniprot ID S1PD64
Locus tag I0P59_RS19700 Protein ID WP_000854753.1
Coordinates 4173485..4173859 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID E3PJ72
Locus tag I0P59_RS19695 Protein ID WP_001278232.1
Coordinates 4173027..4173395 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I0P59_RS19665 (4169863) 4169863..4170318 + 456 WP_000581504.1 IrmA family protein -
I0P59_RS19670 (4170397) 4170397..4170630 + 234 WP_001119729.1 DUF905 family protein -
I0P59_RS19675 (4170730) 4170730..4171548 + 819 WP_001520163.1 DUF932 domain-containing protein -
I0P59_RS19680 (4171603) 4171603..4172088 + 486 WP_001520165.1 antirestriction protein -
I0P59_RS19685 (4172104) 4172104..4172580 + 477 WP_001186726.1 RadC family protein -
I0P59_RS19690 (4172643) 4172643..4172864 + 222 WP_000692316.1 DUF987 domain-containing protein -
I0P59_RS19695 (4173027) 4173027..4173395 + 369 WP_001278232.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
I0P59_RS19700 (4173485) 4173485..4173859 + 375 WP_000854753.1 TA system toxin CbtA family protein Toxin
I0P59_RS19705 (4173856) 4173856..4174344 + 489 WP_000777541.1 DUF5983 family protein -
I0P59_RS19710 (4174356) 4174356..4174553 + 198 WP_000839281.1 DUF957 domain-containing protein -
I0P59_RS19715 (4174650) 4174650..4175219 + 570 WP_001290241.1 DUF4942 domain-containing protein -
I0P59_RS19720 (4175561) 4175561..4175731 + 171 Protein_3885 IS110 family transposase -
I0P59_RS19725 (4176542) 4176542..4177525 + 984 WP_001616958.1 KpsF/GutQ family sugar-phosphate isomerase -
I0P59_RS19730 (4177597) 4177597..4178745 + 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14005.00 Da        Isoelectric Point: 8.2905

>T198795 WP_000854753.1 NZ_CP072787:4173485-4173859 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T198795 NZ_CP097008:c2463359-2463258 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13491.37 Da        Isoelectric Point: 6.6290

>AT198795 WP_001278232.1 NZ_CP072787:4173027-4173395 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT198795 NZ_CP097008:2463134-2463313 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LVU0

Antitoxin

Source ID Structure
AlphaFold DB E3PJ72

References