Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2024086..2024881 Replicon chromosome
Accession NZ_CP072787
Organism Escherichia coli strain NC101

Toxin (Protein)


Gene name yeeV Uniprot ID Q1RDD2
Locus tag I0P59_RS09500 Protein ID WP_001094434.1
Coordinates 2024507..2024881 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag I0P59_RS09495 Protein ID WP_001285482.1
Coordinates 2024086..2024460 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I0P59_RS09470 (2020966) 2020966..2021787 + 822 WP_001234582.1 DUF932 domain-containing protein -
I0P59_RS09475 (2022124) 2022124..2022597 + 474 WP_001313575.1 antirestriction protein -
I0P59_RS09480 (2022613) 2022613..2023089 + 477 WP_001313574.1 RadC family protein -
I0P59_RS09485 (2023152) 2023152..2023373 + 222 WP_000692315.1 DUF987 domain-containing protein -
I0P59_RS09490 (2023392) 2023392..2024036 + 645 WP_000086762.1 hypothetical protein -
I0P59_RS09495 (2024086) 2024086..2024460 + 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I0P59_RS09500 (2024507) 2024507..2024881 + 375 WP_001094434.1 TA system toxin CbtA family protein Toxin
I0P59_RS09505 (2024878) 2024878..2025369 + 492 WP_000976859.1 DUF5983 family protein -
I0P59_RS09510 (2025381) 2025381..2025578 + 198 WP_000839257.1 DUF957 domain-containing protein -
I0P59_RS09515 (2025671) 2025671..2026513 + 843 WP_001280460.1 DUF4942 domain-containing protein -
I0P59_RS09525 (2026984) 2026984..2027922 + 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
I0P59_RS09530 (2027977) 2027977..2028714 + 738 WP_000283656.1 zinc-binding phosphatase -
I0P59_RS09535 (2028738) 2028738..2029292 + 555 WP_001001913.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13921.82 Da        Isoelectric Point: 6.8517

>T198781 WP_001094434.1 NZ_CP072787:2024507-2024881 [Escherichia coli]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

>T198781 NZ_CP097004:c299910-299815 [Enterococcus faecalis]
ATGTACGAGATTGTCACAAAAATTCTTGTGCCGATTTTTGTCGGGATTGTCCTGAAACTTGTAACCATTTGGTTGGAAAA
ACAGAACGAGGAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT198781 WP_001285482.1 NZ_CP072787:2024086-2024460 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT198781 NZ_CP097004:299715-299779 [Enterococcus faecalis]
CTTGTGACAAAGTCGTGCATGGATGCACTAAAAAGACACCCTATTGTGGTAGGGTGTCTTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q1RDD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References