Detailed information of TA system TA198697

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 2891796..2893016
• Replicon: chromosome
• Accession: NZ_CP072783
• Organism: Pseudomonas aeruginosa strain LICME WGH-6

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: J9247_RS13470
• Protein ID: WP_124119800.1
• Coordinates: 2891796..2892374 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A6A9JWC3
• Locus tag: J9247_RS13475
• Protein ID: WP_033978782.1
• Coordinates: 2892462..2893016 (-)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J9247_RS13455 (J9247_13455)	2887072..2888349	+	1278	WP_121350419.1	TolC family protein	-
J9247_RS13460 (J9247_13460)	2888339..2890510	+	2172	WP_058179113.1	type I secretion system permease/ATPase	-
J9247_RS13465 (J9247_13465)	2890500..2891687	+	1188	WP_058173309.1	HlyD family efflux transporter periplasmic adaptor subunit	-
J9247_RS13470 (J9247_13470)	2891796..2892374	-	579	WP_124119800.1	HD domain-containing protein	Toxin
J9247_RS13475 (J9247_13475)	2892462..2893016	-	555	WP_033978782.1	helix-turn-helix transcriptional regulator	Antitoxin
J9247_RS13480 (J9247_13480)	2893171..2895366	-	2196	WP_210225096.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
J9247_RS13485 (J9247_13485)	2895371..2895832	-	462	WP_003102736.1	(2Fe-2S)-binding protein	-
J9247_RS13490 (J9247_13490)	2896163..2896486	+	324	WP_003102734.1	multidrug efflux SMR transporter	-
J9247_RS13495 (J9247_13495)	2896499..2896897	+	399	WP_023436383.1	NADH-quinone oxidoreductase subunit A	-
J9247_RS13500 (J9247_13500)	2896894..2897445	-	552	WP_121289386.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-189)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21855.71 Da
• Isoelectric Point: 5.3655

>T198697 WP_124119800.1 NZ_CP072783:c2892374-2891796 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHLDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKALRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T198697 NZ_CP096956:c4822975-4822610 [Pseudomonas aeruginosa]
GTGGCGTGGGATATCGAGTACACCGACGAGTTCGGTGATTGGTGGGGTTCTCTGTCCGAGGATGAGCAGGAGTCGCTAGC
TGTGACGGTTCGCTTGCTTGAGGAGCGGGGGCCATCCTTGGGGCACCCCCACAGCAGCGGCATCAATGGCTCCCGCCCTG
GCCATATGAGAGAGCTACGGACTCAACACGGCGGGCGACCTTTCCGAACGCTTTACGCGTTTGACCCCAGACGCTCCGCG
ATACTGCCGATCGGTGGCGACAAGACTGGCGATGATCGTTGGTACGAATTGAACGTGCCCATTGCCGACCGCCTCCATGA
CGAACACTTGCACCAGCTCCGTGAGGAGGGACTGATCGATGGCTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20514.68 Da
• Isoelectric Point: 8.1590

>AT198697 WP_033978782.1 NZ_CP072783:c2893016-2892462 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPTRAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANTSAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT198697 NZ_CP096956:c4822617-4822294 [Pseudomonas aeruginosa]
ATGGCTAAGAAATTCTCCGACCTTCGGGCGCAAATGTCGCCTGAGGCACAGGCCCGCGTCGAGGCCAAGGCCCAGGAACT
GTTGGCTGAAATGCCCCTGAATGAGTTGCGCCAGTCTAGAGGCTTGTCGCAGAAGATGCTGTCTGAAGTGCTGCAGGTGC
AGCAGCCGGCAATTGCCAAGATGGAGCGGCGTACGGATATGTACATCTCCACCTTGCGCAGCCACATCGAAGCCATGGGC
GGCCAGCTGGAAGTGATTGCACGCTTCCCGGATGGTGCGGTGAAAATCAGCAACTTCGCGGATATCGAAGAGGCGGGCGC
CTAA

Structures

Antitoxin

• AlphaFold DB: A0A6A9JWC3